======= PTPN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN2
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5771|5771]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17706|P17706]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176887|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF- stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-6-mediated signaling pathway|
|negative regulation of interleukin-2-mediated signaling pathway|
|regulation of interleukin-2-mediated signaling pathway|
|negative regulation of positive thymic T cell selection|
|negative regulation of interleukin-4-mediated signaling pathway|
|negative regulation of macrophage colony-stimulating factor signaling pathway|
|negative regulation of response to macrophage colony-stimulating factor|
|regulation of positive thymic T cell selection|
|negative regulation of cellular response to macrophage colony-stimulating factor stimulus|
|regulation of macrophage colony-stimulating factor signaling pathway|
|regulation of interleukin-6-mediated signaling pathway|
|regulation of interleukin-4-mediated signaling pathway|
|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|
|positive regulation of PERK-mediated unfolded protein response|
|regulation of hepatocyte growth factor receptor signaling pathway|
|regulation of cellular response to macrophage colony-stimulating factor stimulus|
|regulation of response to macrophage colony-stimulating factor|
|negative regulation of response to interferon-gamma|
|negative regulation of macrophage differentiation|
|negative regulation of interferon-gamma-mediated signaling pathway|
|non-membrane spanning protein tyrosine phosphatase activity|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|negative regulation of T cell differentiation in thymus|
|STAT family protein binding|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of PERK-mediated unfolded protein response|
|negative regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of gluconeogenesis|
|positive regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|negative regulation of type I interferon-mediated signaling pathway|
|negative regulation of lipid storage|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of macrophage differentiation|
|regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of T cell differentiation in thymus|
|regulation of endoplasmic reticulum unfolded protein response|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|negative regulation of antigen receptor-mediated signaling pathway|
|negative regulation of protein tyrosine kinase activity|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of insulin receptor signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|positive regulation of response to endoplasmic reticulum stress|
|positive regulation of glucose metabolic process|
|regulation of T cell receptor signaling pathway|
|negative regulation of lipid localization|
|negative regulation of T cell differentiation|
|regulation of gluconeogenesis|
|regulation of lipid storage|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of myeloid leukocyte differentiation|
|negative regulation of ERBB signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte differentiation|
|syntaxin binding|
|negative regulation of innate immune response|
|negative regulation of chemotaxis|
|receptor tyrosine kinase binding|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of insulin receptor signaling pathway|
|negative regulation of response to cytokine stimulus|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of cellular response to insulin stimulus|
|endoplasmic reticulum-Golgi intermediate compartment|
|negative regulation of myeloid cell differentiation|
|positive regulation of carbohydrate metabolic process|
|regulation of tyrosine phosphorylation of STAT protein|
|erythrocyte differentiation|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of response to endoplasmic reticulum stress|
|insulin receptor signaling pathway|
|erythrocyte homeostasis|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|negative regulation of response to biotic stimulus|
|regulation of carbohydrate biosynthetic process|
|negative regulation of leukocyte differentiation|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|myeloid cell homeostasis|
|B cell differentiation|
|negative regulation of T cell activation|
|regulation of glucose metabolic process|
|regulation of myeloid leukocyte differentiation|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of receptor signaling pathway via JAK-STAT|
|integrin binding|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|negative regulation of hemopoiesis|
|negative regulation of inflammatory response|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|regulation of T cell differentiation|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|B cell activation|
|regulation of intrinsic apoptotic signaling pathway|
|cellular response to insulin stimulus|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|positive regulation of apoptotic signaling pathway|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of cell activation|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|regulation of chemotaxis|
|protein dephosphorylation|
|negative regulation of multi-organism process|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|negative regulation of protein kinase activity|
|response to insulin|
|T cell activation|
|lymphocyte differentiation|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|cellular response to peptide hormone stimulus|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|dephosphorylation|
|regulation of T cell activation|
|negative regulation of locomotion|
|cellular response to peptide|
|leukocyte differentiation|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of innate immune response|
|protein kinase binding|
|response to peptide|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|response to hormone|
|leukocyte activation|
|negative regulation of developmental process|
|regulation of transferase activity|
|regulation of locomotion|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.34|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.92|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.82|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17748
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN2 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>