======= PTPRO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRO
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type O
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5800|5800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16827|Q16827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). {ECO:0000250, ECO:0000269|PubMed:19167335}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|filtration diaphragm assembly|
|slit diaphragm assembly|
|negative regulation of retinal ganglion cell axon guidance|
|negative regulation of glomerular filtration|
|regulation of retinal ganglion cell axon guidance|
|regulation of glomerular filtration|
|renal system process involved in regulation of blood volume|
|glomerular visceral epithelial cell differentiation|
|renal filtration cell differentiation|
|glomerular epithelial cell differentiation|
|transmembrane receptor protein tyrosine phosphatase activity|
|glomerular epithelium development|
|renal system process involved in regulation of systemic arterial blood pressure|
|negative regulation of axon guidance|
|epithelial cell differentiation involved in kidney development|
|lamellipodium assembly|
|regulation of renal system process|
|Wnt-protein binding|
|cell differentiation involved in kidney development|
|lamellipodium organization|
|monocyte chemotaxis|
|regulation of axon guidance|
|phosphatase activity|
|mononuclear cell migration|
|integral component of postsynaptic density membrane|
|glomerulus development|
|lateral plasma membrane|
|negative regulation of chemotaxis|
|negative regulation of cell-substrate adhesion|
|GABA-ergic synapse|
|negative regulation of axonogenesis|
|regulation of systemic arterial blood pressure|
|nephron epithelium development|
|negative regulation of cell morphogenesis involved in differentiation|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|cell-cell junction assembly|
|renal system process|
|nephron development|
|myeloid leukocyte migration|
|growth cone|
|kidney epithelium development|
|cell-cell junction organization|
|leukocyte chemotaxis|
|dendritic spine|
|negative regulation of neuron projection development|
|cell junction assembly|
|negative regulation of canonical Wnt signaling pathway|
|lamellipodium|
|negative regulation of cell projection organization|
|regulation of blood pressure|
|regulation of axonogenesis|
|cell chemotaxis|
|negative regulation of Wnt signaling pathway|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|protein dephosphorylation|
|cell junction organization|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|axon guidance|
|neuron projection guidance|
|kidney development|
|negative regulation of cell adhesion|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|dephosphorylation|
|cadherin binding|
|negative regulation of nervous system development|
|apical plasma membrane|
|urogenital system development|
|neuron projection|
|negative regulation of locomotion|
|negative regulation of cell development|
|glutamatergic synapse|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|axonogenesis|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|regulation of body fluid levels|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of system process|
|regulation of neuron differentiation|
|neuron projection development|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRO Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>