======= PVRL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NECTIN2
  * **<color #00a2e8>Official Name</color>**: nectin cell adhesion molecule 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5819|5819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92692|Q92692]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PVRL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PVRL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor-mediated virion attachment to host cell|
|susceptibility to T cell mediated cytotoxicity|
|sperm mitochondrion organization|
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|fusion of virus membrane with host plasma membrane|
|membrane fusion involved in viral entry into host cell|
|multi-organism membrane fusion|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|zonula adherens|
|regulation of natural killer cell mediated immune response to tumor cell|
|virion attachment to host cell|
|multi-organism membrane organization|
|susceptibility to natural killer cell mediated cytotoxicity|
|positive regulation of response to tumor cell|
|positive regulation of immune response to tumor cell|
|adhesion of symbiont to host cell|
|adhesion of symbiont to host|
|regulation of immune response to tumor cell|
|regulation of response to tumor cell|
|positive regulation of T cell receptor signaling pathway|
|acrosome assembly|
|positive regulation of mast cell activation|
|cell-cell contact zone|
|spermatid nucleus differentiation|
|multi-organism cellular process|
|positive regulation of antigen receptor-mediated signaling pathway|
|establishment of mitochondrion localization|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of viral entry into host cell|
|positive regulation of natural killer cell mediated immunity|
|regulation of T cell mediated cytotoxicity|
|secretory granule organization|
|coreceptor activity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|regulation of T cell receptor signaling pathway|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|regulation of mast cell activation|
|mitochondrion localization|
|positive regulation of T cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|cell adhesion molecule binding|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|virus receptor activity|
|regulation of leukocyte mediated cytotoxicity|
|adherens junction organization|
|viral entry into host cell|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|entry into host cell|
|entry into host|
|cellular component assembly involved in morphogenesis|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|membrane fusion|
|positive regulation of leukocyte mediated immunity|
|nucleus organization|
|regulation of viral life cycle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|spermatid development|
|interaction with host|
|spermatid differentiation|
|regulation of adaptive immune response|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|fertilization|
|cell-cell junction|
|viral life cycle|
|regulation of leukocyte mediated immunity|
|regulation of viral process|
|cell junction organization|
|positive regulation of immune effector process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|germ cell development|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|vesicle organization|
|positive regulation of innate immune response|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of response to biotic stimulus|
|establishment of organelle localization|
|cilium organization|
|positive regulation of leukocyte activation|
|focal adhesion|
|positive regulation of cell activation|
|endomembrane system organization|
|mitochondrion organization|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|cell part morphogenesis|
|regulation of response to biotic stimulus|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|developmental process involved in reproduction|
|gamete generation|
|viral process|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|positive regulation of immune response|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|multi-organism reproductive process|
|identical protein binding|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|reproductive process|
|reproduction|
|regulation of response to stress|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.36|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.23|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PVRL2 Expression in NALM6 Cells: 2.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>