======= PXN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PXN
  * **<color #00a2e8>Official Name</color>**: paxillin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5829|5829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49023|P49023]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PXN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PXN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|Paxillin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal complex assembly|
|vinculin binding|
|neuropilin binding|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|microtubule associated complex|
|response to growth hormone|
|positive regulation of stress fiber assembly|
|substrate adhesion-dependent cell spreading|
|positive regulation of actin filament bundle assembly|
|adherens junction|
|endothelial cell migration|
|vascular endothelial growth factor receptor signaling pathway|
|stress fiber|
|regulation of stress fiber assembly|
|transcription coregulator activity|
|beta-catenin binding|
|epithelial cell migration|
|protein phosphatase binding|
|epithelium migration|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|tissue migration|
|transforming growth factor beta receptor signaling pathway|
|cellular response to reactive oxygen species|
|integrin binding|
|cell cortex|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|ameboidal-type cell migration|
|lamellipodium|
|cell-substrate adhesion|
|response to reactive oxygen species|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of cytoskeleton organization|
|cellular response to oxidative stress|
|muscle contraction|
|regulation of actin filament organization|
|cellular response to peptide hormone stimulus|
|ubiquitin protein ligase binding|
|muscle system process|
|cellular response to peptide|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|response to oxidative stress|
|regulation of actin filament-based process|
|response to peptide hormone|
|focal adhesion|
|protein kinase binding|
|response to peptide|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|response to hormone|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|locomotion|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cell development|
|cellular response to stress|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11986
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PXN Expression in NALM6 Cells: 4.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>