======= RAB11FIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB11FIP2
  * **<color #00a2e8>Official Name</color>**: RAB11 family interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22841|22841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L804|Q7L804]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB11FIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB11FIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|RBD-FIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAM-dependent toll-like receptor 4 signaling pathway|
|TRAM-dependent toll-like receptor signaling pathway|
|insulin secretion involved in cellular response to glucose stimulus|
|toll-like receptor 4 signaling pathway|
|phagocytic cup|
|MyD88-independent toll-like receptor signaling pathway|
|renal water homeostasis|
|insulin secretion|
|positive regulation of protein localization to plasma membrane|
|peptide hormone secretion|
|positive regulation of protein localization to cell periphery|
|multicellular organismal water homeostasis|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|hormone secretion|
|cellular response to monosaccharide stimulus|
|water homeostasis|
|cellular response to carbohydrate stimulus|
|hormone transport|
|recycling endosome membrane|
|cellular glucose homeostasis|
|regulation of protein localization to plasma membrane|
|cell projection|
|toll-like receptor signaling pathway|
|renal system process|
|regulation of protein localization to cell periphery|
|establishment of cell polarity|
|positive regulation of protein localization to membrane|
|pattern recognition receptor signaling pathway|
|response to glucose|
|cytoplasmic vesicle membrane|
|response to hexose|
|response to monosaccharide|
|Rab GTPase binding|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|establishment or maintenance of cell polarity|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|endosome|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|phagocytosis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of GTPase activity|
|regulation of innate immune response|
|protein kinase binding|
|positive regulation of defense response|
|regulation of GTPase activity|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|regulation of hormone levels|
|regulation of cellular protein localization|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|cellular chemical homeostasis|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|exocytosis|
|positive regulation of immune response|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cellular localization|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|identical protein binding|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.469|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB11FIP2 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>