======= RAB1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB1A
  * **<color #00a2e8>Official Name</color>**: RAB1A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5861|5861]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62820|P62820]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. {ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
|Ras|
|GTP EFTU|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-8 secretion|
|growth hormone secretion|
|interleukin-8 production|
|positive regulation of ubiquitin protein ligase activity|
|COPII-coated vesicle cargo loading|
|establishment of endothelial intestinal barrier|
|melanosome transport|
|establishment of melanosome localization|
|positive regulation of glycoprotein metabolic process|
|regulation of ubiquitin protein ligase activity|
|pigment granule transport|
|establishment of pigment granule localization|
|melanosome localization|
|pigment granule localization|
|vesicle cargo loading|
|positive regulation of ubiquitin-protein transferase activity|
|establishment of endothelial barrier|
|virion assembly|
|transport vesicle membrane|
|vesicle transport along microtubule|
|regulation of glycoprotein metabolic process|
|cellular pigmentation|
|cytokine secretion|
|vesicle cytoskeletal trafficking|
|endothelial cell development|
|regulation of ubiquitin-protein transferase activity|
|substrate adhesion-dependent cell spreading|
|peptide hormone secretion|
|autophagosome assembly|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|autophagosome organization|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|hormone secretion|
|Rab protein signal transduction|
|Golgi vesicle budding|
|organelle transport along microtubule|
|hormone transport|
|endothelial cell differentiation|
|localization within membrane|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle targeting|
|pigmentation|
|endothelium development|
|vesicle budding from membrane|
|melanosome|
|positive regulation of protein ubiquitination|
|vacuole organization|
|Golgi organization|
|positive regulation of protein modification by small protein conjugation or removal|
|cytokine production|
|transport along microtubule|
|protein secretion|
|establishment of protein localization to extracellular region|
|macroautophagy|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|cell-substrate adhesion|
|epithelial cell development|
|regulation of protein ubiquitination|
|viral life cycle|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein modification by small protein conjugation or removal|
|Ras protein signal transduction|
|early endosome|
|process utilizing autophagic mechanism|
|autophagy|
|microtubule-based movement|
|vesicle organization|
|cadherin binding|
|small GTPase mediated signal transduction|
|defense response to bacterium|
|GTPase activity|
|cilium assembly|
|post-translational protein modification|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|GTP binding|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of hormone levels|
|endocytosis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|Golgi membrane|
|positive regulation of transferase activity|
|microtubule-based process|
|import into cell|
|epithelial cell differentiation|
|response to bacterium|
|viral process|
|cell morphogenesis|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|membrane organization|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|Golgi apparatus|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.46|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.75|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.17|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.78|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.04|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab1b|RAB1B]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB1A Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>