======= RAB21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB21
  * **<color #00a2e8>Official Name</color>**: RAB21, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23011|23011]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL25|Q9UL25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of early endosome membrane|
|positive regulation of early endosome to late endosome transport|
|positive regulation of cytoplasmic transport|
|regulation of early endosome to late endosome transport|
|regulation of cytoplasmic transport|
|vesicle membrane|
|positive regulation of dendrite morphogenesis|
|anterograde axonal transport|
|positive regulation of receptor-mediated endocytosis|
|cytoplasmic side of plasma membrane|
|cleavage furrow|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|Rab protein signal transduction|
|positive regulation of dendrite development|
|GDP binding|
|regulation of dendrite morphogenesis|
|Golgi cisterna membrane|
|regulation of axon extension|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|regulation of extent of cell growth|
|cytoplasmic vesicle membrane|
|regulation of dendrite development|
|early endosome membrane|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|trans-Golgi network|
|cytoskeleton-dependent intracellular transport|
|regulation of cell size|
|microtubule-based transport|
|regulation of axonogenesis|
|regulation of endocytosis|
|positive regulation of intracellular transport|
|regulation of exocytosis|
|Ras protein signal transduction|
|early endosome|
|synapse|
|endosome|
|microtubule-based movement|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|regulation of developmental growth|
|GTPase activity|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|GTP binding|
|focal adhesion|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|positive regulation of transport|
|intracellular protein transport|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.87|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.74|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.73|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.8|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0196|KIAA0196]]|0.457|
|[[:human genes:c:ccdc53|CCDC53]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5165
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB21 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>