======= RAB4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB4A
  * **<color #00a2e8>Official Name</color>**: RAB4A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5867|5867]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20338|P20338]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic recycling endosome|
|insulin-responsive compartment|
|anchored component of synaptic vesicle membrane|
|ATPase activator activity|
|ionotropic glutamate receptor binding|
|positive regulation of ATPase activity|
|syntaxin binding|
|Rab protein signal transduction|
|GDP binding|
|ATPase binding|
|regulation of ATPase activity|
|recycling endosome membrane|
|phosphatidylinositol biosynthetic process|
|vesicle|
|cytoplasmic vesicle membrane|
|early endosome membrane|
|phosphatidylinositol metabolic process|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|antigen processing and presentation|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|Ras protein signal transduction|
|endosome|
|glycerophospholipid metabolic process|
|small GTPase mediated signal transduction|
|GTPase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|GTP binding|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|lipid biosynthetic process|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|positive regulation of hydrolase activity|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|intracellular protein transport|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.89|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.78|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.78|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.73|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.71|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.72|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB4A Expression in NALM6 Cells: 4.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>