======= RAB5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB5A
  * **<color #00a2e8>Official Name</color>**: RAB5A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5868|5868]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20339|P20339]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell- containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of early endosome membrane|
|postsynaptic early endosome|
|receptor internalization involved in canonical Wnt signaling pathway|
|regulation of endosome size|
|amyloid-beta clearance by transcytosis|
|early phagosome|
|somatodendritic compartment|
|viral RNA genome replication|
|anchored component of synaptic vesicle membrane|
|transcytosis|
|amyloid-beta clearance|
|early endosome to late endosome transport|
|vesicle-mediated transport between endosomal compartments|
|viral genome replication|
|regulation of long-term neuronal synaptic plasticity|
|regulation of autophagosome assembly|
|regulation of vacuole organization|
|regulation of filopodium assembly|
|terminal bouton|
|axon terminus|
|synaptic vesicle recycling|
|clathrin-coated vesicle membrane|
|regulation of neuronal synaptic plasticity|
|endocytic vesicle|
|phagocytic vesicle|
|receptor internalization|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|GDP binding|
|regulation of synaptic vesicle exocytosis|
|positive regulation of exocytosis|
|canonical Wnt signaling pathway|
|ruffle|
|melanosome|
|receptor metabolic process|
|regulation of neurotransmitter secretion|
|phosphatidylinositol biosynthetic process|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|cytosolic transport|
|early endosome membrane|
|regulation of regulated secretory pathway|
|phosphatidylinositol metabolic process|
|regulation of macroautophagy|
|regulation of synaptic plasticity|
|regulation of plasma membrane bounded cell projection assembly|
|viral life cycle|
|regulation of cell projection assembly|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|endosome membrane|
|actin cytoskeleton|
|regulation of organelle assembly|
|glycerolipid biosynthetic process|
|regulation of exocytosis|
|membrane raft|
|receptor-mediated endocytosis|
|phospholipid biosynthetic process|
|Ras protein signal transduction|
|early endosome|
|endosome|
|blood coagulation|
|coagulation|
|axon|
|hemostasis|
|glycerophospholipid metabolic process|
|small GTPase mediated signal transduction|
|phagocytosis|
|GTPase activity|
|regulation of autophagy|
|regulation of neurotransmitter levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|post-translational protein modification|
|neuronal cell body|
|phospholipid metabolic process|
|regulation of cellular component size|
|glycerolipid metabolic process|
|GTP binding|
|positive regulation of secretion by cell|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|wound healing|
|regulation of body fluid levels|
|regulation of anatomical structure size|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|endocytosis|
|response to wounding|
|lipid biosynthetic process|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|organophosphate metabolic process|
|regulation of cellular localization|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|regulation of catabolic process|
|cell-cell signaling|
|lipid metabolic process|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB5A Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>