======= RABEP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RABEP1
  * **<color #00a2e8>Official Name</color>**: rabaptin, RAB GTPase binding effector protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9135|9135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15276|Q15276]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RABEP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RABEP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603616|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. {ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rab5-bind|
|Rabaptin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to ciliary membrane|
|protein localization to cilium|
|endocytic vesicle|
|Golgi to plasma membrane transport|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|recycling endosome|
|membrane fusion|
|early endosome membrane|
|growth factor activity|
|protein localization to cell periphery|
|protein domain specific binding|
|early endosome|
|endosome|
|GTPase activator activity|
|Golgi vesicle transport|
|positive regulation of GTPase activity|
|protein localization to membrane|
|regulation of GTPase activity|
|endocytosis|
|protein-containing complex|
|import into cell|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|membrane organization|
|protein homodimerization activity|
|apoptotic process|
|programmed cell death|
|cell death|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.05|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.75|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.74|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.77|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.97|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RABEP1 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>