======= RAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAC1
  * **<color #00a2e8>Official Name</color>**: Rac family small GTPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5879|5879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63000|P63000]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-23 production|
|Rho GDP-dissociation inhibitor binding|
|mast cell migration|
|mast cell chemotaxis|
|regulation of interleukin-23 production|
|thioesterase binding|
|ruffle assembly|
|hepatocyte growth factor receptor signaling pathway|
|regulation of respiratory burst|
|positive regulation of lamellipodium assembly|
|regulation of hydrogen peroxide metabolic process|
|Rac protein signal transduction|
|negative regulation of receptor-mediated endocytosis|
|bone resorption|
|positive regulation of neutrophil chemotaxis|
|ruffle organization|
|positive regulation of focal adhesion assembly|
|positive regulation of granulocyte chemotaxis|
|motor neuron axon guidance|
|positive regulation of lamellipodium organization|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|positive regulation of Rho protein signal transduction|
|regulation of lamellipodium assembly|
|positive regulation of microtubule polymerization|
|regulation of defense response to virus by virus|
|actin filament polymerization|
|positive regulation of adherens junction organization|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of cell junction assembly|
|lamellipodium assembly|
|positive regulation of microtubule polymerization or depolymerization|
|regulation of neutrophil migration|
|regulation of cofactor metabolic process|
|positive regulation of DNA replication|
|semaphorin-plexin signaling pathway|
|positive regulation of substrate adhesion-dependent cell spreading|
|lamellipodium organization|
|regulation of lamellipodium organization|
|regulation of granulocyte chemotaxis|
|negative regulation of endocytosis|
|bone remodeling|
|actin polymerization or depolymerization|
|positive regulation of stress fiber assembly|
|regulation of microtubule polymerization|
|positive regulation of cell-matrix adhesion|
|substrate adhesion-dependent cell spreading|
|regulation of substrate adhesion-dependent cell spreading|
|T cell costimulation|
|lymphocyte costimulation|
|regulation of nitric oxide biosynthetic process|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|ficolin-1-rich granule membrane|
|positive regulation of actin filament bundle assembly|
|positive regulation of Ras protein signal transduction|
|regulation of adherens junction organization|
|vascular endothelial growth factor receptor signaling pathway|
|cytoplasmic ribonucleoprotein granule|
|positive regulation of small GTPase mediated signal transduction|
|positive regulation of insulin secretion|
|Rho protein signal transduction|
|cellular response to mechanical stimulus|
|regulation of stress fiber assembly|
|ATPase binding|
|regulation of microtubule polymerization or depolymerization|
|actin filament|
|recycling endosome membrane|
|postsynapse|
|localization within membrane|
|regulation of reactive oxygen species biosynthetic process|
|ephrin receptor signaling pathway|
|protein polymerization|
|positive regulation of leukocyte chemotaxis|
|regulation of actomyosin structure organization|
|regulation of cell junction assembly|
|regulation of actin filament bundle assembly|
|ruffle membrane|
|positive regulation of peptide hormone secretion|
|Wnt signaling pathway, planar cell polarity pathway|
|secretory granule membrane|
|cell projection|
|regulation of receptor-mediated endocytosis|
|melanosome|
|tissue remodeling|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of DNA replication|
|histone deacetylase binding|
|regulation of establishment of planar polarity|
|regulation of leukocyte chemotaxis|
|regulation of cell-matrix adhesion|
|neuron migration|
|positive regulation of cell-substrate adhesion|
|cell-matrix adhesion|
|positive regulation of protein polymerization|
|positive regulation of hormone secretion|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|non-canonical Wnt signaling pathway|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|positive regulation of chemotaxis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of Rho protein signal transduction|
|leukocyte chemotaxis|
|dendritic spine|
|Rab GTPase binding|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of protein kinase B signaling|
|trans-Golgi network|
|Fc-epsilon receptor signaling pathway|
|regulation of insulin secretion|
|regulation of reactive oxygen species metabolic process|
|lamellipodium|
|regulation of morphogenesis of an epithelium|
|regulation of cell size|
|cell-substrate adhesion|
|regulation of microtubule cytoskeleton organization|
|tissue homeostasis|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|positive regulation of T cell activation|
|regulation of cell projection assembly|
|regulation of endocytosis|
|regulation of peptide hormone secretion|
|cell chemotaxis|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|response to mechanical stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|protein-containing complex binding|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|multicellular organismal homeostasis|
|phagocytosis|
|GTPase activity|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|enzyme binding|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|positive regulation of lymphocyte activation|
|axonogenesis|
|regulation of cellular component size|
|leukocyte migration|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|GTP binding|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|focal adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|neutrophil degranulation|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|regulation of anatomical structure size|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|actin filament-based process|
|response to wounding|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|Golgi membrane|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|viral process|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of cellular localization|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.72|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.72|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.76|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.96|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.01|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.04|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.92|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.07|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 127/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|1/28|
|bone|4/26|
|breast|4/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|5/21|
|liver|3/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|6/26|
|pancreas|8/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7066
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAC1 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>