======= RALB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RALB
  * **<color #00a2e8>Official Name</color>**: RAS like proto-oncogene B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5899|5899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11234|P11234]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RALB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RALB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). {ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of exocyst localization|
|regulation of exocyst assembly|
|regulation of vesicle docking|
|positive regulation of autophagosome assembly|
|positive regulation of vacuole organization|
|cellular response to exogenous dsRNA|
|cellular response to dsRNA|
|regulation of autophagosome assembly|
|regulation of vacuole organization|
|response to exogenous dsRNA|
|response to dsRNA|
|positive regulation of macroautophagy|
|positive regulation of organelle assembly|
|GDP binding|
|ATPase binding|
|positive regulation of protein binding|
|negative regulation of protein binding|
|positive regulation of autophagy|
|cellular response to starvation|
|midbody|
|negative regulation of binding|
|regulation of macroautophagy|
|positive regulation of binding|
|response to starvation|
|regulation of protein binding|
|regulation of organelle assembly|
|regulation of exocytosis|
|cellular response to nutrient levels|
|Ras protein signal transduction|
|cellular response to extracellular stimulus|
|ubiquitin protein ligase binding|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of autophagy|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|regulation of binding|
|GTP binding|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|cell division|
|response to nutrient levels|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of secretion by cell|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.21|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.81|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RALB Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>