======= RAMP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAMP1
  * **<color #00a2e8>Official Name</color>**: receptor activity modifying protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10267|10267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60894|O60894]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAMP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAMP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. {ECO:0000269|PubMed:9620797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RAMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcitonin gene-related peptide binding|
|CGRP receptor complex|
|amylin receptor complex 1|
|calcitonin gene-related peptide receptor signaling pathway|
|calcitonin gene-related peptide receptor activity|
|amylin receptor activity|
|amylin receptor signaling pathway|
|calcitonin family receptor signaling pathway|
|positive regulation of protein glycosylation|
|regulation of protein glycosylation|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of glycoprotein metabolic process|
|coreceptor activity|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|receptor internalization|
|cell|
|receptor metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|protein localization to plasma membrane|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|angiogenesis|
|second-messenger-mediated signaling|
|blood vessel morphogenesis|
|protein localization to membrane|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|endocytosis|
|cellular response to hormone stimulus|
|cell surface|
|metal ion transport|
|tube morphogenesis|
|import into cell|
|cation transport|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|intracellular protein transport|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.94|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAMP1 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>