======= RAPGEF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPGEF6
  * **<color #00a2e8>Official Name</color>**: Rap guanine nucleotide exchange factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51735|51735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEU7|Q8TEU7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPGEF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPGEF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RA|
|PDZ|
|RasGEF|
|cNMP binding|
|RasGEF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of endothelial intestinal barrier|
|Ras GTPase binding|
|microvillus assembly|
|phosphatidic acid binding|
|microvillus organization|
|GTP-dependent protein binding|
|establishment of endothelial barrier|
|endothelial cell development|
|endocytic vesicle|
|endothelial cell differentiation|
|endothelium development|
|guanyl-nucleotide exchange factor activity|
|protein localization to plasma membrane|
|epithelial cell development|
|protein localization to cell periphery|
|Ras protein signal transduction|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|regulation of GTPase activity|
|centrosome|
|epithelial cell differentiation|
|positive regulation of hydrolase activity|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.99|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.94|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.86|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.85|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.82|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.75|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.7|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPGEF6 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>