======= RARG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RARG
  * **<color #00a2e8>Official Name</color>**: retinoic acid receptor gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5916|5916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13631|P13631]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RARG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RARG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth plate cartilage chondrocyte growth|
|growth plate cartilage chondrocyte development|
|chondrocyte hypertrophy|
|Harderian gland development|
|trachea cartilage development|
|retinoic acid receptor signaling pathway|
|retinoid X receptor binding|
|glandular epithelial cell development|
|trachea development|
|prostate gland epithelium morphogenesis|
|negative regulation of chondrocyte differentiation|
|growth plate cartilage chondrocyte differentiation|
|prostate gland morphogenesis|
|chondrocyte development involved in endochondral bone morphogenesis|
|embryonic hindlimb morphogenesis|
|negative regulation of cartilage development|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|embryonic eye morphogenesis|
|growth plate cartilage development|
|hindlimb morphogenesis|
|embryonic camera-type eye development|
|glandular epithelial cell differentiation|
|prostate gland development|
|regulation of myelination|
|endochondral bone growth|
|chondrocyte development|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|nuclear receptor activity|
|face development|
|columnar/cuboidal epithelial cell development|
|regulation of chondrocyte differentiation|
|steroid hormone receptor activity|
|nuclear receptor transcription coactivator activity|
|cellular response to retinoic acid|
|regulation of cartilage development|
|RNA polymerase II transcription factor complex|
|endochondral bone morphogenesis|
|transcription regulatory region sequence-specific DNA binding|
|chondrocyte differentiation|
|multicellular organism growth|
|developmental cell growth|
|canonical Wnt signaling pathway|
|cell growth|
|neural tube closure|
|tube closure|
|columnar/cuboidal epithelial cell differentiation|
|organ growth|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|primary neural tube formation|
|gland morphogenesis|
|neural tube formation|
|response to retinoic acid|
|bone morphogenesis|
|developmental growth involved in morphogenesis|
|steroid hormone mediated signaling pathway|
|embryonic epithelial tube formation|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|eye morphogenesis|
|appendage morphogenesis|
|limb morphogenesis|
|neural tube development|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cartilage development|
|transcription initiation from RNA polymerase II promoter|
|appendage development|
|limb development|
|regulation of cell size|
|cellular response to steroid hormone stimulus|
|epithelial cell development|
|respiratory system development|
|bone development|
|signaling receptor activity|
|transcription factor complex|
|cellular response to acid chemical|
|anterior/posterior pattern specification|
|DNA-templated transcription, initiation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|response to steroid hormone|
|transcription factor binding|
|regionalization|
|response to acid chemical|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|regulation of cellular component size|
|developmental growth|
|growth|
|gland development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|skeletal system development|
|regulation of anatomical structure size|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cellular response to hormone stimulus|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|head development|
|zinc ion binding|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RARG Expression in NALM6 Cells: 2.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>