======= RASA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASA2
  * **<color #00a2e8>Official Name</color>**: RAS p21 protein activator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5922|5922]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15283|Q15283]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601589|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|RasGAP|
|BTK|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|phospholipid binding|
|regulation of Ras protein signal transduction|
|GTPase activator activity|
|regulation of small GTPase mediated signal transduction|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|perinuclear region of cytoplasm|
|positive regulation of hydrolase activity|
|protein phosphorylation|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.15|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.76|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.9|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nf1|NF1]]|0.457|
|[[:human genes:l:lztr1|LZTR1]]|0.423|
|[[:human genes:d:dusp6|DUSP6]]|0.421|
|[[:human genes:d:dgkd|DGKD]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17760
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASA2 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>