======= RASGRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASGRP1
  * **<color #00a2e8>Official Name</color>**: RAS guanyl releasing protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10125|10125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95267|O95267]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASGRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASGRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF|
|C1 1|
|RasGEF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of natural killer cell differentiation|
|positive regulation of interferon-gamma secretion|
|secretory granule localization|
|positive regulation of T cell differentiation in thymus|
|regulation of interferon-gamma secretion|
|diacylglycerol binding|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of natural killer cell differentiation|
|Ras guanyl-nucleotide exchange factor activity|
|regulation of granulocyte macrophage colony-stimulating factor production|
|mast cell degranulation|
|mast cell activation involved in immune response|
|mast cell mediated immunity|
|positive regulation of natural killer cell activation|
|mast cell granule|
|mast cell activation|
|inflammatory response to antigenic stimulus|
|regulation of T cell differentiation in thymus|
|phosphatidylcholine binding|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell activation|
|positive regulation of natural killer cell mediated immunity|
|regulation of p38MAPK cascade|
|regulation of natural killer cell mediated cytotoxicity|
|vesicle transport along microtubule|
|lysosome localization|
|regulation of natural killer cell mediated immunity|
|regulation of phospholipase C activity|
|vesicle cytoskeletal trafficking|
|positive regulation of leukocyte mediated cytotoxicity|
|phosphatidylserine binding|
|positive regulation of interferon-gamma production|
|positive regulation of Ras protein signal transduction|
|positive regulation of cell killing|
|positive regulation of small GTPase mediated signal transduction|
|regulation of phospholipase activity|
|regulation of leukocyte mediated cytotoxicity|
|organelle transport along microtubule|
|positive regulation of T cell differentiation|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of lymphocyte differentiation|
|activation of GTPase activity|
|regulation of lipase activity|
|regulation of interferon-gamma production|
|regulation of cell killing|
|guanyl-nucleotide exchange factor activity|
|positive regulation of lymphocyte mediated immunity|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of leukocyte mediated immunity|
|regulation of T cell differentiation|
|positive regulation of JNK cascade|
|positive regulation of cytokine secretion|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|lipid binding|
|transport along microtubule|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of lymphocyte differentiation|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|positive regulation of protein secretion|
|microtubule-based movement|
|regulation of leukocyte differentiation|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|establishment of organelle localization|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of GTPase activity|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|organelle localization|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|zinc ion binding|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|leukocyte activation|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|intracellular transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.05|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6231
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASGRP1 Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>