======= RBBP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBBP5
  * **<color #00a2e8>Official Name</color>**: RB binding protein 5, histone lysine methyltransferase complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5929|5929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15291|Q15291]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBBP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBBP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600697|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:19556245}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Set1C/COMPASS complex|
|MLL3/4 complex|
|histone methyltransferase activity (H3-K4 specific)|
|beta-catenin-TCF complex assembly|
|MLL1 complex|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|regulation of megakaryocyte differentiation|
|methylated histone binding|
|histone lysine methylation|
|response to estrogen|
|peptidyl-lysine methylation|
|histone methylation|
|protein methylation|
|protein alkylation|
|transcription regulatory region DNA binding|
|regulation of myeloid cell differentiation|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|post-translational protein modification|
|histone modification|
|covalent chromatin modification|
|regulation of hemopoiesis|
|chromatin organization|
|cellular response to DNA damage stimulus|
|nucleolus|
|peptidyl-amino acid modification|
|chromosome organization|
|protein-containing complex assembly|
|regulation of immune system process|
|cellular response to stress|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.85|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.8|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.554|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.547|
|[[:human genes:r:rps5|RPS5]]|0.545|
|[[:human genes:c:c14orf93|C14orf93]]|0.543|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.542|
|[[:human genes:p:psmb4|PSMB4]]|0.536|
|[[:human genes:r:rps2|RPS2]]|0.524|
|[[:human genes:a:akirin2|AKIRIN2]]|0.521|
|[[:human genes:r:rps28|RPS28]]|0.517|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.517|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.516|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.516|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.516|
|[[:human genes:r:rps12|RPS12]]|0.514|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.511|
|[[:human genes:p:pola1|POLA1]]|0.51|
|[[:human genes:c:cbwd5|CBWD5]]|0.509|
|[[:human genes:p:pwp2|PWP2]]|0.502|
|[[:human genes:c:cbwd3|CBWD3]]|0.501|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.497|
|[[:human genes:k:kctd17|KCTD17]]|0.493|
|[[:human genes:p:pola2|POLA2]]|0.491|
|[[:human genes:s:sec13|SEC13]]|0.491|
|[[:human genes:d:ddtl|DDTL]]|0.488|
|[[:human genes:b:bysl|BYSL]]|0.486|
|[[:human genes:c:cdc73|CDC73]]|0.486|
|[[:human genes:m:med17|MED17]]|0.483|
|[[:human genes:t:trim52|TRIM52]]|0.483|
|[[:human genes:v:vasn|VASN]]|0.482|
|[[:human genes:r:rpl35|RPL35]]|0.48|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.479|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:n:nop16|NOP16]]|0.477|
|[[:human genes:r:rpl6|RPL6]]|0.476|
|[[:human genes:i:iscu|ISCU]]|0.476|
|[[:human genes:p:psma6|PSMA6]]|0.475|
|[[:human genes:n:npipb5|NPIPB5]]|0.475|
|[[:human genes:o:or10g3|OR10G3]]|0.474|
|[[:human genes:r:rpl38|RPL38]]|0.473|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.472|
|[[:human genes:c:copg1|COPG1]]|0.472|
|[[:human genes:s:ssh2|SSH2]]|0.472|
|[[:human genes:n:nup160|NUP160]]|0.471|
|[[:human genes:t:tfip11|TFIP11]]|0.47|
|[[:human genes:s:sf3a1|SF3A1]]|0.47|
|[[:human genes:z:znf106|ZNF106]]|0.468|
|[[:human genes:c:cbwd6|CBWD6]]|0.467|
|[[:human genes:r:rps19|RPS19]]|0.467|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.466|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.465|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:g:gga3|GGA3]]|0.462|
|[[:human genes:u:utp20|UTP20]]|0.462|
|[[:human genes:w:wdr87|WDR87]]|0.46|
|[[:human genes:c:chd4|CHD4]]|0.459|
|[[:human genes:h:hap1|HAP1]]|0.459|
|[[:human genes:a:aqr|AQR]]|0.458|
|[[:human genes:d:disp2|DISP2]]|0.457|
|[[:human genes:r:rps7|RPS7]]|0.456|
|[[:human genes:s:slc4a1|SLC4A1]]|0.456|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.455|
|[[:human genes:n:nbpf10|NBPF10]]|0.454|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.454|
|[[:human genes:p:psmd11|PSMD11]]|0.454|
|[[:human genes:p:psmd1|PSMD1]]|0.452|
|[[:human genes:o:orc1|ORC1]]|0.451|
|[[:human genes:r:ranbp2|RANBP2]]|0.45|
|[[:human genes:s:stil|STIL]]|0.449|
|[[:human genes:s:syt9|SYT9]]|0.447|
|[[:human genes:o:ogfr|OGFR]]|0.446|
|[[:human genes:r:rbm39|RBM39]]|0.444|
|[[:human genes:m:myh2|MYH2]]|0.444|
|[[:human genes:f:fam160a1|FAM160A1]]|0.443|
|[[:human genes:s:s1pr4|S1PR4]]|0.441|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.441|
|[[:human genes:t:twistnb|TWISTNB]]|0.44|
|[[:human genes:p:psmb1|PSMB1]]|0.44|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.44|
|[[:human genes:t:tspy8|TSPY8]]|0.44|
|[[:human genes:n:nop14|NOP14]]|0.439|
|[[:human genes:c:c3|C3]]|0.439|
|[[:human genes:c:copa|COPA]]|0.439|
|[[:human genes:r:rpl30|RPL30]]|0.438|
|[[:human genes:m:myo1h|MYO1H]]|0.437|
|[[:human genes:c:ccna2|CCNA2]]|0.437|
|[[:human genes:s:supt5h|SUPT5H]]|0.437|
|[[:human genes:c:ckap5|CKAP5]]|0.437|
|[[:human genes:r:rffl|RFFL]]|0.437|
|[[:human genes:c:cactin|CACTIN]]|0.437|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.436|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.435|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.434|
|[[:human genes:n:nup133|NUP133]]|0.434|
|[[:human genes:p:psmc2|PSMC2]]|0.434|
|[[:human genes:n:nupl1|NUPL1]]|0.434|
|[[:human genes:p:psmd14|PSMD14]]|0.433|
|[[:human genes:z:zfand5|ZFAND5]]|0.433|
|[[:human genes:p:psmd6|PSMD6]]|0.432|
|[[:human genes:u:utp3|UTP3]]|0.431|
|[[:human genes:r:rrn3|RRN3]]|0.43|
|[[:human genes:f:fam25b|FAM25B]]|0.43|
|[[:human genes:r:rps20|RPS20]]|0.43|
|[[:human genes:r:rps11|RPS11]]|0.429|
|[[:human genes:e:exosc5|EXOSC5]]|0.428|
|[[:human genes:r:rad21|RAD21]]|0.427|
|[[:human genes:f:fbxo5|FBXO5]]|0.426|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.426|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.426|
|[[:human genes:m:mcoln1|MCOLN1]]|0.425|
|[[:human genes:h:hivep3|HIVEP3]]|0.425|
|[[:human genes:a:aamp|AAMP]]|0.424|
|[[:human genes:t:ticrr|TICRR]]|0.424|
|[[:human genes:m:mt1e|MT1E]]|0.424|
|[[:human genes:p:ppan|PPAN]]|0.424|
|[[:human genes:m:myt1l|MYT1L]]|0.424|
|[[:human genes:c:cdc45|CDC45]]|0.423|
|[[:human genes:k:kif3c|KIF3C]]|0.423|
|[[:human genes:x:xab2|XAB2]]|0.422|
|[[:human genes:p:psap|PSAP]]|0.422|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.422|
|[[:human genes:p:polr2f|POLR2F]]|0.421|
|[[:human genes:m:myo18a|MYO18A]]|0.421|
|[[:human genes:s:supt6h|SUPT6H]]|0.421|
|[[:human genes:s:slc38a7|SLC38A7]]|0.421|
|[[:human genes:s:snrpa1|SNRPA1]]|0.419|
|[[:human genes:m:med14|MED14]]|0.418|
|[[:human genes:g:golga8o|GOLGA8O]]|0.418|
|[[:human genes:d:ddx56|DDX56]]|0.416|
|[[:human genes:m:myb|MYB]]|0.416|
|[[:human genes:o:orc6|ORC6]]|0.416|
|[[:human genes:t:tagln|TAGLN]]|0.416|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.415|
|[[:human genes:n:nup107|NUP107]]|0.414|
|[[:human genes:p:psma1|PSMA1]]|0.414|
|[[:human genes:s:slc6a17|SLC6A17]]|0.414|
|[[:human genes:u:upf1|UPF1]]|0.412|
|[[:human genes:o:or11h6|OR11H6]]|0.412|
|[[:human genes:p:psmc6|PSMC6]]|0.412|
|[[:human genes:n:npipb8|NPIPB8]]|0.409|
|[[:human genes:w:wdr46|WDR46]]|0.408|
|[[:human genes:s:srrm2|SRRM2]]|0.408|
|[[:human genes:a:aprt|APRT]]|0.407|
|[[:human genes:d:ddt|DDT]]|0.407|
|[[:human genes:c:chchd3|CHCHD3]]|0.407|
|[[:human genes:c:copz1|COPZ1]]|0.406|
|[[:human genes:n:napa|NAPA]]|0.406|
|[[:human genes:n:nbpf16|NBPF16]]|0.406|
|[[:human genes:s:snrnp70|SNRNP70]]|0.405|
|[[:human genes:m:mdm2|MDM2]]|0.405|
|[[:human genes:l:lad1|LAD1]]|0.404|
|[[:human genes:k:krt78|KRT78]]|0.404|
|[[:human genes:g:gosr2|GOSR2]]|0.404|
|[[:human genes:r:rpsa|RPSA]]|0.404|
|[[:human genes:p:palb2|PALB2]]|0.404|
|[[:human genes:s:sf3a3|SF3A3]]|0.404|
|[[:human genes:c:cgb2|CGB2]]|0.404|
|[[:human genes:s:sfpq|SFPQ]]|0.403|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.403|
|[[:human genes:p:psmb3|PSMB3]]|0.402|
|[[:human genes:r:rrp15|RRP15]]|0.402|
|[[:human genes:t:top1mt|TOP1MT]]|0.402|
|[[:human genes:i:igfn1|IGFN1]]|0.402|
|[[:human genes:n:nup43|NUP43]]|0.401|
|[[:human genes:e:egr2|EGR2]]|0.401|
|[[:human genes:r:riok2|RIOK2]]|0.4|
|[[:human genes:c:cdca3|CDCA3]]|0.4|
|[[:human genes:r:rnf113a|RNF113A]]|0.4|
|[[:human genes:c:cnot1|CNOT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 643/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|26/28|
|bone|22/25|
|breast|27/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|14/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|11/14|
|ovary|20/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBBP5 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>