======= RBM14-RBM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM14-RBM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM14-RBM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCHC|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.51|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.34|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.32|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.3|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.24|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.22|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.18|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.11|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.1|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.05|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.98|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.98|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.96|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.92|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.88|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.87|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.87|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.86|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.84|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.83|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.82|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.78|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.78|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.72|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.71|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.7|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.83|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.89|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.01|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.29|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.31|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.32|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.4|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.43|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.74|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.8|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.41|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|4.76|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|5.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|5.25|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|5.5|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|5.72|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|5.82|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|5.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM14-RBM4 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>