======= RBM22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM22
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55696|55696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NW64|Q9NW64]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U6 snRNA binding|
|U2-type catalytic step 1 spliceosome|
|Prp19 complex|
|pre-mRNA binding|
|positive regulation of protein export from nucleus|
|U2-type catalytic step 2 spliceosome|
|mRNA cis splicing, via spliceosome|
|positive regulation of RNA splicing|
|positive regulation of protein import into nucleus|
|regulation of protein export from nucleus|
|positive regulation of protein import|
|regulation of protein import into nucleus|
|regulation of protein import|
|calcium-dependent protein binding|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|catalytic step 2 spliceosome|
|regulation of nucleocytoplasmic transport|
|regulation of protein localization to nucleus|
|regulation of RNA splicing|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|RNA splicing|
|cellular response to drug|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|mRNA processing|
|regulation of cellular protein localization|
|mRNA metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|RNA processing|
|regulation of cellular localization|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|RNA binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.75|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.7|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.79|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.86|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.04|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.12|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.22|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sap30bp|SAP30BP]]|0.463|
|[[:human genes:p:polr2j3|POLR2J3]]|0.449|
|[[:human genes:c:ctr9|CTR9]]|0.416|
|[[:human genes:p:prim1|PRIM1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM22 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>