======= RBM25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM25
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58517|58517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49756|P49756]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|PWI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA binding|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.88|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.75|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.7|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.78|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.8|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.81|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.88|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.05|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.21|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.74|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 723/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|23/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 793
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM25 Expression in NALM6 Cells: 8.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>