======= RBM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM5
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10181|10181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52756|P52756]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606884|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch 2|
|zf-RanBP|
|RRM 1|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|positive regulation of cell death|
|cellular protein-containing complex assembly|
|RNA processing|
|apoptotic process|
|programmed cell death|
|cell death|
|RNA binding|
|DNA binding|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|RNA metabolic process|
|regulation of cell death|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.27|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.66|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.51|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.38|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.35|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.22|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.16|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.06|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.02|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.01|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.92|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.87|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.82|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.81|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.87|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM5 Expression in NALM6 Cells: 8.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>