======= RBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBP1
  * **<color #00a2e8>Official Name</color>**: retinol binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5947|5947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09455|P09455]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). {ECO:0000269|PubMed:15632377, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:26900151, ECO:0000269|PubMed:28057518}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|all-trans-retinol binding|
|retinoid binding|
|vitamin A metabolic process|
|retinoic acid biosynthetic process|
|diterpenoid biosynthetic process|
|retinal binding|
|terpenoid biosynthetic process|
|isoprenoid biosynthetic process|
|retinoic acid metabolic process|
|fat-soluble vitamin metabolic process|
|lipid droplet|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|lipid homeostasis|
|isoprenoid metabolic process|
|monocarboxylic acid biosynthetic process|
|hormone metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|homeostatic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.76|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBP1 Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>