======= RBPMS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBPMS2
  * **<color #00a2e8>Official Name</color>**: RNA binding protein, mRNA processing factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=348093|348093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZRY4|Q6ZRY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBPMS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBPMS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation. {ECO:0000250|UniProtKB:Q9W6I1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of smooth muscle cell differentiation|
|embryonic digestive tract morphogenesis|
|regulation of smooth muscle cell differentiation|
|embryonic digestive tract development|
|digestive tract morphogenesis|
|negative regulation of BMP signaling pathway|
|negative regulation of muscle cell differentiation|
|positive regulation of smooth muscle cell proliferation|
|regulation of BMP signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|digestive tract development|
|regulation of smooth muscle cell proliferation|
|digestive system development|
|negative regulation of cellular response to growth factor stimulus|
|regulation of muscle cell differentiation|
|mRNA binding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|embryonic organ morphogenesis|
|embryonic organ development|
|embryonic morphogenesis|
|tube morphogenesis|
|negative regulation of cell differentiation|
|tube development|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.89|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.87|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6932
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBPMS2 Expression in NALM6 Cells: -2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>