======= RECQL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RECQL5
  * **<color #00a2e8>Official Name</color>**: RecQ like helicase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9400|9400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94762|O94762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RECQL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RECQL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ResIII|
|DEAD|
|RecQ5|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to camptothecin|
|replication-born double-strand break repair via sister chromatid exchange|
|four-way junction helicase activity|
|response to camptothecin|
|RNA polymerase II, holoenzyme|
|negative regulation of transcription elongation from RNA polymerase II promoter|
|DNA unwinding involved in DNA replication|
|negative regulation of DNA-templated transcription, elongation|
|3-5 DNA helicase activity|
|negative regulation of double-strand break repair via homologous recombination|
|regulation of transcription elongation from RNA polymerase II promoter|
|chromosome separation|
|negative regulation of double-strand break repair|
|RNA polymerase II complex binding|
|negative regulation of DNA repair|
|cellular response to alkaloid|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|regulation of DNA-templated transcription, elongation|
|DNA helicase activity|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|cellular response to alcohol|
|response to antineoplastic agent|
|double-strand break repair via homologous recombination|
|recombinational repair|
|regulation of DNA recombination|
|DNA duplex unwinding|
|response to alkaloid|
|DNA geometric change|
|DNA-dependent DNA replication|
|negative regulation of DNA metabolic process|
|chromosome|
|regulation of DNA repair|
|double-strand break repair|
|nucleic acid binding|
|DNA replication|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|response to alcohol|
|chromosome segregation|
|DNA conformation change|
|regulation of DNA metabolic process|
|cellular response to drug|
|cell division|
|DNA repair|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|response to organic cyclic compound|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-3.89|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-3|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.95|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.67|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.93|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.87|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RECQL5 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>