======= REN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REN
  * **<color #00a2e8>Official Name</color>**: renin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5972|5972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00797|P00797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Asp|
|A1 Propeptide|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renin-angiotensin regulation of aldosterone production|
|regulation of mineralocorticoid secretion|
|regulation of aldosterone secretion|
|response to cGMP|
|regulation of blood volume by renin-angiotensin|
|drinking behavior|
|angiotensin maturation|
|regulation of angiotensin levels in blood|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|regulation of corticosteroid hormone secretion|
|insulin-like growth factor receptor binding|
|regulation of steroid hormone secretion|
|amyloid-beta metabolic process|
|aspartic-type endopeptidase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|renal system process involved in regulation of systemic arterial blood pressure|
|response to immobilization stress|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|regulation of endocrine process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|apical part of cell|
|peptidase activity|
|feeding behavior|
|mesonephros development|
|regulation of systemic arterial blood pressure|
|response to cAMP|
|regulation of lipid transport|
|renal system process|
|male gonad development|
|development of primary male sexual characteristics|
|response to organophosphorus|
|regulation of lipid localization|
|response to purine-containing compound|
|male sex differentiation|
|cell maturation|
|protein processing|
|hormone-mediated signaling pathway|
|regulation of blood pressure|
|hormone metabolic process|
|gonad development|
|development of primary sexual characteristics|
|protein maturation|
|developmental maturation|
|sex differentiation|
|kidney development|
|regulation of hormone secretion|
|renal system development|
|response to lipopolysaccharide|
|urogenital system development|
|response to molecule of bacterial origin|
|signaling receptor binding|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|reproductive structure development|
|reproductive system development|
|peptide metabolic process|
|regulation of hormone levels|
|behavior|
|regulation of system process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|response to bacterium|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|cellular amide metabolic process|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|cell development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.86|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.84|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.79|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.77|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.81|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.36|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4434
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REN Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>