======= RFT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFT1
  * **<color #00a2e8>Official Name</color>**: RFT1 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91869|91869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AA3|Q96AA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611908|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. {ECO:0000269|PubMed:18313027}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rft-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycolipid translocation|
|glycolipid transport|
|lipid transporter activity|
|lipid translocation|
|regulation of membrane lipid distribution|
|carbohydrate derivative transport|
|carbohydrate transport|
|lipid transport|
|lipid localization|
|membrane organization|
|endoplasmic reticulum membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.611|
|[[:human genes:t:trmt61a|TRMT61A]]|0.587|
|[[:human genes:d:dolk|DOLK]]|0.549|
|[[:human genes:f:fh|FH]]|0.546|
|[[:human genes:p:ppcs|PPCS]]|0.543|
|[[:human genes:r:rpp21|RPP21]]|0.539|
|[[:human genes:a:atxn10|ATXN10]]|0.533|
|[[:human genes:t:tpk1|TPK1]]|0.531|
|[[:human genes:s:srd5a3|SRD5A3]]|0.524|
|[[:human genes:d:dnlz|DNLZ]]|0.524|
|[[:human genes:a:alg6|ALG6]]|0.521|
|[[:human genes:t:ten1|TEN1]]|0.518|
|[[:human genes:p:pgm3|PGM3]]|0.516|
|[[:human genes:a:alg1|ALG1]]|0.516|
|[[:human genes:d:dpagt1|DPAGT1]]|0.515|
|[[:human genes:d:dhrsx|DHRSX]]|0.51|
|[[:human genes:c:c15orf41|C15orf41]]|0.508|
|[[:human genes:r:rtcb|RTCB]]|0.507|
|[[:human genes:s:ssb|SSB]]|0.505|
|[[:human genes:p:ppcdc|PPCDC]]|0.502|
|[[:human genes:v:vezt|VEZT]]|0.497|
|[[:human genes:l:lsm10|LSM10]]|0.492|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.488|
|[[:human genes:g:gemin6|GEMIN6]]|0.488|
|[[:human genes:t:tbcb|TBCB]]|0.485|
|[[:human genes:p:ppp6c|PPP6C]]|0.481|
|[[:human genes:p:ppa2|PPA2]]|0.481|
|[[:human genes:r:rpia|RPIA]]|0.48|
|[[:human genes:p:pmvk|PMVK]]|0.477|
|[[:human genes:u:uap1|UAP1]]|0.476|
|[[:human genes:g:gemin8|GEMIN8]]|0.475|
|[[:human genes:t:triap1|TRIAP1]]|0.474|
|[[:human genes:d:dohh|DOHH]]|0.473|
|[[:human genes:t:tsen54|TSEN54]]|0.473|
|[[:human genes:t:trmt6|TRMT6]]|0.471|
|[[:human genes:a:atic|ATIC]]|0.47|
|[[:human genes:r:rabggtb|RABGGTB]]|0.469|
|[[:human genes:s:srp14|SRP14]]|0.467|
|[[:human genes:p:pars2|PARS2]]|0.466|
|[[:human genes:m:med16|MED16]]|0.461|
|[[:human genes:k:kdsr|KDSR]]|0.458|
|[[:human genes:p:pmm2|PMM2]]|0.457|
|[[:human genes:f:fen1|FEN1]]|0.455|
|[[:human genes:g:gfpt1|GFPT1]]|0.455|
|[[:human genes:g:gemin7|GEMIN7]]|0.451|
|[[:human genes:m:mbtps2|MBTPS2]]|0.446|
|[[:human genes:a:alg13|ALG13]]|0.442|
|[[:human genes:d:dars2|DARS2]]|0.441|
|[[:human genes:a:alg8|ALG8]]|0.439|
|[[:human genes:z:zrsr2|ZRSR2]]|0.436|
|[[:human genes:p:ppa1|PPA1]]|0.435|
|[[:human genes:d:ddx1|DDX1]]|0.435|
|[[:human genes:p:ptar1|PTAR1]]|0.433|
|[[:human genes:c:ctc1|CTC1]]|0.433|
|[[:human genes:s:sec62|SEC62]]|0.432|
|[[:human genes:t:trmt10a|TRMT10A]]|0.431|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.431|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.429|
|[[:human genes:a:adsl|ADSL]]|0.429|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.429|
|[[:human genes:w:wdr92|WDR92]]|0.429|
|[[:human genes:g:gmppb|GMPPB]]|0.428|
|[[:human genes:g:gatc|GATC]]|0.428|
|[[:human genes:t:tprkb|TPRKB]]|0.425|
|[[:human genes:u:uhrf1|UHRF1]]|0.424|
|[[:human genes:e:elp3|ELP3]]|0.423|
|[[:human genes:t:timm22|TIMM22]]|0.422|
|[[:human genes:e:elac2|ELAC2]]|0.422|
|[[:human genes:p:polg|POLG]]|0.421|
|[[:human genes:t:timm10|TIMM10]]|0.419|
|[[:human genes:t:ttc4|TTC4]]|0.418|
|[[:human genes:d:dr1|DR1]]|0.418|
|[[:human genes:g:gnb1l|GNB1L]]|0.417|
|[[:human genes:r:rfk|RFK]]|0.417|
|[[:human genes:c:cbfb|CBFB]]|0.417|
|[[:human genes:m:mrpl23|MRPL23]]|0.416|
|[[:human genes:t:trmt5|TRMT5]]|0.415|
|[[:human genes:e:exoc4|EXOC4]]|0.415|
|[[:human genes:r:rptor|RPTOR]]|0.415|
|[[:human genes:m:msto1|MSTO1]]|0.414|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.413|
|[[:human genes:u:utp23|UTP23]]|0.412|
|[[:human genes:d:dap3|DAP3]]|0.41|
|[[:human genes:a:atp5o|ATP5O]]|0.409|
|[[:human genes:r:rnmt|RNMT]]|0.408|
|[[:human genes:e:elp2|ELP2]]|0.407|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.406|
|[[:human genes:a:atp5b|ATP5B]]|0.405|
|[[:human genes:s:slc25a19|SLC25A19]]|0.405|
|[[:human genes:d:ddx55|DDX55]]|0.404|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.402|
|[[:human genes:s:slc25a26|SLC25A26]]|0.401|
|[[:human genes:n:nbn|NBN]]|0.401|
|[[:human genes:l:lsm11|LSM11]]|0.401|
|[[:human genes:m:mrps34|MRPS34]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 540/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|18/28|
|bone|18/26|
|breast|19/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|16/21|
|liver|18/20|
|lung|52/75|
|lymphocyte|8/16|
|ovary|19/26|
|pancreas|24/24|
|peripheral nervous system|12/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 659
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFT1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>