======= RGN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGN
  * **<color #00a2e8>Official Name</color>**: regucalcin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9104|9104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15493|Q15493]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300212|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SGL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of aminoacyl-tRNA ligase activity|
|regulation of dUTP diphosphatase activity|
|gluconolactonase activity|
|regulation of calcium-dependent ATPase activity|
|regulation of leucine-tRNA ligase activity|
|positive regulation of dUTP diphosphatase activity|
|negative regulation of leucine-tRNA ligase activity|
|negative regulation of calcium-dependent ATPase activity|
|L-ascorbic acid biosynthetic process|
|negative regulation of ligase activity|
|regulation of aminoacyl-tRNA ligase activity|
|positive regulation of removal of superoxide radicals|
|positive regulation of superoxide dismutase activity|
|negative regulation of DNA catabolic process|
|regulation of superoxide dismutase activity|
|negative regulation of cilium-dependent cell motility|
|negative regulation of flagellated sperm motility|
|positive regulation of ATPase-coupled calcium transmembrane transporter activity|
|negative regulation of cyclic-nucleotide phosphodiesterase activity|
|positive regulation of response to reactive oxygen species|
|regulation of ligase activity|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|water-soluble vitamin biosynthetic process|
|regulation of removal of superoxide radicals|
|negative regulation of bone development|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|L-ascorbic acid metabolic process|
|positive regulation of triglyceride biosynthetic process|
|regulation of DNA catabolic process|
|negative regulation of nitric oxide biosynthetic process|
|negative regulation of nitric oxide metabolic process|
|enzyme regulator activity|
|vitamin biosynthetic process|
|positive regulation of cellular response to oxidative stress|
|regulation of flagellated sperm motility|
|regulation of triglyceride biosynthetic process|
|positive regulation of triglyceride metabolic process|
|positive regulation of response to oxidative stress|
|negative regulation of ATPase activity|
|positive regulation of fatty acid biosynthetic process|
|regulation of bone development|
|regulation of cilium-dependent cell motility|
|negative regulation of reactive oxygen species biosynthetic process|
|liver regeneration|
|regulation of superoxide metabolic process|
|positive regulation of fatty acid metabolic process|
|positive regulation of phosphatase activity|
|regulation of response to reactive oxygen species|
|regulation of triglyceride metabolic process|
|positive regulation of glucose metabolic process|
|negative regulation of DNA biosynthetic process|
|positive regulation of calcium ion transmembrane transporter activity|
|regulation of fatty acid biosynthetic process|
|negative regulation of GTPase activity|
|monosaccharide biosynthetic process|
|positive regulation of oxidoreductase activity|
|negative regulation of reactive oxygen species metabolic process|
|positive regulation of ATPase activity|
|negative regulation of reproductive process|
|regulation of nitric oxide biosynthetic process|
|positive regulation of dephosphorylation|
|positive regulation of cellular carbohydrate metabolic process|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|positive regulation of calcium ion transmembrane transport|
|animal organ regeneration|
|regulation of cellular response to oxidative stress|
|positive regulation of carbohydrate metabolic process|
|positive regulation of lipid biosynthetic process|
|regulation of ATPase activity|
|regulation of response to oxidative stress|
|regulation of reactive oxygen species biosynthetic process|
|regulation of fatty acid metabolic process|
|water-soluble vitamin metabolic process|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|regulation of calcium-mediated signaling|
|positive regulation of ion transmembrane transporter activity|
|negative regulation of phosphatase activity|
|positive regulation of transporter activity|
|negative regulation of dephosphorylation|
|regulation of DNA biosynthetic process|
|regulation of glucose metabolic process|
|regulation of phosphoprotein phosphatase activity|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of DNA metabolic process|
|positive regulation of calcium ion transport|
|negative regulation of epithelial cell proliferation|
|vitamin metabolic process|
|liver development|
|carbohydrate biosynthetic process|
|hepaticobiliary system development|
|coenzyme biosynthetic process|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|regulation of protein dephosphorylation|
|positive regulation of cellular protein catabolic process|
|positive regulation of lipid metabolic process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regeneration|
|regulation of reproductive process|
|regulation of cellular ketone metabolic process|
|regulation of phosphatase activity|
|regulation of reactive oxygen species metabolic process|
|regulation of lipid biosynthetic process|
|monosaccharide metabolic process|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|regulation of dephosphorylation|
|cofactor biosynthetic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of cellular protein catabolic process|
|coenzyme metabolic process|
|negative regulation of cellular catabolic process|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|kidney development|
|negative regulation of cell motility|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|aging|
|renal system development|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|urogenital system development|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|regulation of cation transmembrane transport|
|regulation of neurotransmitter levels|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|gland development|
|positive regulation of GTPase activity|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|cofactor metabolic process|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|spermatogenesis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|male gamete generation|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|negative regulation of cell population proliferation|
|gamete generation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|zinc ion binding|
|multicellular organism reproduction|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17683
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGN Expression in NALM6 Cells: 0.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>