======= RGS14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGS14
  * **<color #00a2e8>Official Name</color>**: regulator of G protein signaling 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10636|10636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43566|O43566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGS14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGS14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602513|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)- mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal- based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GoLoco|
|RBD|
|RGS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zygote asymmetric cell division|
|negative regulation of synaptic plasticity|
|GDP-dissociation inhibitor activity|
|asymmetric cell division|
|GTPase activating protein binding|
|receptor signaling complex adaptor activity|
|G-protein alpha-subunit binding|
|long-term memory|
|platelet-derived growth factor receptor signaling pathway|
|long-term synaptic potentiation|
|negative regulation of G protein-coupled receptor signaling pathway|
|visual learning|
|visual behavior|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of MAP kinase activity|
|associative learning|
|PML body|
|memory|
|spindle|
|spindle pole|
|regulation of DNA-templated transcription in response to stress|
|negative regulation of protein serine/threonine kinase activity|
|regulation of G protein-coupled receptor signaling pathway|
|learning|
|dendritic spine|
|positive regulation of synaptic transmission|
|spindle organization|
|negative regulation of MAPK cascade|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|negative regulation of protein kinase activity|
|microtubule binding|
|negative regulation of kinase activity|
|postsynaptic density|
|learning or memory|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|negative regulation of transferase activity|
|GTPase activator activity|
|nuclear body|
|regulation of ERK1 and ERK2 cascade|
|cognition|
|response to light stimulus|
|microtubule|
|GTPase activity|
|regulation of MAP kinase activity|
|glutamatergic synapse|
|response to oxidative stress|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|dendrite|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|protein kinase binding|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|centrosome|
|cell division|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|negative regulation of protein modification process|
|microtubule-based process|
|mitotic cell cycle|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|generation of neurons|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.7|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.75|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGS14 Expression in NALM6 Cells: 3.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>