======= RHBDD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHBDD1
  * **<color #00a2e8>Official Name</color>**: rhomboid domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84236|84236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEB9|Q8TEB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHBDD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHBDD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. {ECO:0000269|PubMed:18953687, ECO:0000269|PubMed:22624035}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhomboid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|
|regulation of male germ cell proliferation|
|regulation of germ cell proliferation|
|retrograde protein transport, ER to cytosol|
|endoplasmic reticulum to cytosol transport|
|membrane protein intracellular domain proteolysis|
|endoplasmic reticulum quality control compartment|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|protein exit from endoplasmic reticulum|
|membrane protein proteolysis|
|regulation of protein processing|
|regulation of protein maturation|
|endopeptidase activity|
|cellular response to UV|
|ERAD pathway|
|integral component of endoplasmic reticulum membrane|
|cellular response to light stimulus|
|cellular response to unfolded protein|
|response to UV|
|cellular response to topologically incorrect protein|
|spermatid differentiation|
|regulation of reproductive process|
|response to unfolded protein|
|serine-type endopeptidase activity|
|cellular response to radiation|
|response to topologically incorrect protein|
|response to endoplasmic reticulum stress|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of proteolysis|
|post-translational protein modification|
|response to radiation|
|spermatogenesis|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|developmental process involved in reproduction|
|protein catabolic process|
|gamete generation|
|regulation of proteolysis|
|regulation of multi-organism process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|endoplasmic reticulum membrane|
|multi-organism reproductive process|
|negative regulation of cell death|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cell death|
|response to abiotic stimulus|
|mitochondrion|
|proteolysis|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13711
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHBDD1 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>