======= RHOU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOU
  * **<color #00a2e8>Official Name</color>**: ras homolog family member U
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58480|58480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L0Q8|Q7L0Q8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cdc42 protein signal transduction|
|Rac protein signal transduction|
|podosome|
|positive regulation of protein targeting to mitochondrion|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|Rho protein signal transduction|
|regulation of protein targeting|
|cell projection|
|positive regulation of mitochondrion organization|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|cell cortex|
|regulation of cell shape|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|establishment or maintenance of cell polarity|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|actin filament organization|
|Ras protein signal transduction|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|regulation of actin filament-based process|
|GTP binding|
|focal adhesion|
|positive regulation of protein transport|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|mitotic cell cycle process|
|Golgi membrane|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|import into cell|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|positive regulation of transport|
|cell cycle process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|cytoskeleton organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOU Expression in NALM6 Cells: 0.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>