======= RIC8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIC8A
  * **<color #00a2e8>Official Name</color>**: RIC8 guanine nucleotide exchange factor A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60626|60626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPQ8|Q9NPQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIC8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIC8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609146|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ric8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell adhesion involved in gastrulation|
|cell migration involved in gastrulation|
|basement membrane organization|
|G-protein alpha-subunit binding|
|visual learning|
|visual behavior|
|associative learning|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|guanyl-nucleotide exchange factor activity|
|learning|
|gastrulation|
|ameboidal-type cell migration|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|learning or memory|
|GTPase activator activity|
|cognition|
|response to light stimulus|
|extracellular matrix organization|
|in utero embryonic development|
|extracellular structure organization|
|positive regulation of GTPase activity|
|response to radiation|
|regulation of GTPase activity|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|embryonic morphogenesis|
|behavior|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|positive regulation of hydrolase activity|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|cell motility|
|localization of cell|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.76|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.68|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.53|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.36|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.34|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.31|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.23|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.23|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.17|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.15|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.08|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.08|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.06|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.02|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.97|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.95|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.93|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.75|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.9|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.17|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.26|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.36|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.44|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.51|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.69|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.94|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.44|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gna13|GNA13]]|0.656|
|[[:human genes:a:arhgef1|ARHGEF1]]|0.54|
|[[:human genes:r:rhoa|RHOA]]|0.515|
|[[:human genes:s:strada|STRADA]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18971
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIC8A Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>