======= RICTOR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RICTOR
  * **<color #00a2e8>Official Name</color>**: RPTOR independent companion of MTOR complex 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=253260|253260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6R327|Q6R327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RICTOR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RICTOR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609022|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TORC2 complex|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|TOR signaling|
|activation of protein kinase B activity|
|positive regulation of TOR signaling|
|enzyme activator activity|
|ribosome binding|
|actin cytoskeleton reorganization|
|positive regulation of actin filament polymerization|
|positive regulation of endothelial cell proliferation|
|regulation of TOR signaling|
|establishment of cell polarity|
|positive regulation of protein polymerization|
|regulation of endothelial cell proliferation|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of protein kinase B signaling|
|regulation of actin filament polymerization|
|peptidyl-serine phosphorylation|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|peptidyl-serine modification|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|regulation of protein polymerization|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of actin filament organization|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|protein kinase binding|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|actin filament-based process|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|viral process|
|regulation of defense response|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.72|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.75|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.78|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.81|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.83|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.84|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.85|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.86|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.88|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.91|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.97|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.98|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.04|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.07|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.13|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.18|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.18|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.2|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.23|
|[[:results:exp453|B02 10μM R08 exp453]]|2.24|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.24|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.36|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.37|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.38|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.39|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.46|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.67|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.81|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.94|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.23|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|3.23|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.31|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|3.39|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.65|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.65|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.84|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.9|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.98|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.99|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.27|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|6.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapkap1|MAPKAP1]]|0.821|
|[[:human genes:a:akt2|AKT2]]|0.741|
|[[:human genes:p:pdpk1|PDPK1]]|0.71|
|[[:human genes:p:pik3cd|PIK3CD]]|0.702|
|[[:human genes:c:cd19|CD19]]|0.691|
|[[:human genes:c:cd81|CD81]]|0.666|
|[[:human genes:m:mlst8|MLST8]]|0.661|
|[[:human genes:s:syk|SYK]]|0.63|
|[[:human genes:r:rhoh|RHOH]]|0.627|
|[[:human genes:a:akt1|AKT1]]|0.531|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.515|
|[[:human genes:i:igll1|IGLL1]]|0.507|
|[[:human genes:v:vezf1|VEZF1]]|0.456|
|[[:human genes:g:gnas|GNAS]]|0.45|
|[[:human genes:p:prrc2c|PRRC2C]]|0.442|
|[[:human genes:p:pmaip1|PMAIP1]]|0.426|
|[[:human genes:h:h2afz|H2AFZ]]|0.418|
|[[:human genes:b:bak1|BAK1]]|0.415|
|[[:human genes:c:cd79a|CD79A]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|1/26|
|breast|7/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RICTOR Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>