======= RNASEH2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNASEH2B
  * **<color #00a2e8>Official Name</color>**: ribonuclease H2 subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79621|79621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TBB1|Q5TBB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNASEH2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNASEH2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610326|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase H2-Ydr279|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonuclease H2 complex|
|regulation of DNA damage checkpoint|
|RNA-DNA hybrid ribonuclease activity|
|regulation of cell cycle checkpoint|
|positive regulation of fibroblast proliferation|
|regulation of fibroblast proliferation|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|regulation of response to DNA damage stimulus|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|regulation of mitotic cell cycle phase transition|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|regulation of cell cycle phase transition|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|organophosphate metabolic process|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|embryo development|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of cell cycle|
|regulation of response to stress|
|regulation of cell population proliferation|
|RNA metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-3.08|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.68|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.37|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.33|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.02|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.99|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.91|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.75|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.7|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnaseh2a|RNASEH2A]]|0.52|
|[[:human genes:r:rabggtb|RABGGTB]]|0.502|
|[[:human genes:i:itpa|ITPA]]|0.484|
|[[:human genes:s:spr|SPR]]|0.464|
|[[:human genes:r:rpp21|RPP21]]|0.457|
|[[:human genes:p:ppp4c|PPP4C]]|0.431|
|[[:human genes:e:elp2|ELP2]]|0.425|
|[[:human genes:m:mcm9|MCM9]]|0.417|
|[[:human genes:k:kpna4|KPNA4]]|0.416|
|[[:human genes:e:exoc4|EXOC4]]|0.41|
|[[:human genes:t:tsen54|TSEN54]]|0.407|
|[[:human genes:f:ftsj1|FTSJ1]]|0.406|
|[[:human genes:m:mcm8|MCM8]]|0.404|
|[[:human genes:r:rnaseh2c|RNASEH2C]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNASEH2B Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>