======= RNF113A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF113A
  * **<color #00a2e8>Official Name</color>**: ring finger protein 113A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7737|7737]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15541|O15541]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF113A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF113A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isopeptide cross-linking via N6-glycyl-L-lysine|
|snoRNA splicing|
|isopeptide cross-linking|
|peptidyl-glycine modification|
|negative regulation of chemokine-mediated signaling pathway|
|U2-type spliceosomal complex|
|regulation of chemokine-mediated signaling pathway|
|snoRNA processing|
|snoRNA metabolic process|
|U2-type precatalytic spliceosome|
|peptide cross-linking|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|ubiquitin-protein transferase activity|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|peptidyl-lysine modification|
|ncRNA processing|
|RNA splicing|
|nuclear speck|
|ncRNA metabolic process|
|mRNA processing|
|DNA repair|
|protein ubiquitination|
|mRNA metabolic process|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|RNA processing|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|RNA metabolic process|
|cellular response to stress|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.61|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.43|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.4|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.83|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.71|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.77|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.83|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.88|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.95|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.01|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.04|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.11|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.19|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf148|ZNF148]]|0.51|
|[[:human genes:t:tceb3c|TCEB3C]]|0.5|
|[[:human genes:r:rbm39|RBM39]]|0.494|
|[[:human genes:i:ints5|INTS5]]|0.494|
|[[:human genes:p:psmb4|PSMB4]]|0.485|
|[[:human genes:r:rps2|RPS2]]|0.484|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.481|
|[[:human genes:r:rpl35|RPL35]]|0.479|
|[[:human genes:s:slc6a17|SLC6A17]]|0.477|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.475|
|[[:human genes:p:prim1|PRIM1]]|0.47|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.47|
|[[:human genes:c:cactin|CACTIN]]|0.469|
|[[:human genes:m:myo1h|MYO1H]]|0.465|
|[[:human genes:p:psma6|PSMA6]]|0.463|
|[[:human genes:s:sart1|SART1]]|0.46|
|[[:human genes:n:narfl|NARFL]]|0.45|
|[[:human genes:t:ticrr|TICRR]]|0.446|
|[[:human genes:d:ddtl|DDTL]]|0.446|
|[[:human genes:g:golga8o|GOLGA8O]]|0.445|
|[[:human genes:c:cep192|CEP192]]|0.444|
|[[:human genes:i:iscu|ISCU]]|0.444|
|[[:human genes:s:sf3a3|SF3A3]]|0.439|
|[[:human genes:s:snip1|SNIP1]]|0.436|
|[[:human genes:c:chd4|CHD4]]|0.436|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.432|
|[[:human genes:r:rps3a|RPS3A]]|0.431|
|[[:human genes:e:eif3g|EIF3G]]|0.431|
|[[:human genes:z:zfand5|ZFAND5]]|0.429|
|[[:human genes:p:psmd14|PSMD14]]|0.428|
|[[:human genes:d:dtl|DTL]]|0.427|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.425|
|[[:human genes:r:rps12|RPS12]]|0.424|
|[[:human genes:o:orc1|ORC1]]|0.424|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.424|
|[[:human genes:c:cdc73|CDC73]]|0.423|
|[[:human genes:k:kctd17|KCTD17]]|0.423|
|[[:human genes:w:wdr75|WDR75]]|0.422|
|[[:human genes:s:sf3a1|SF3A1]]|0.421|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.421|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.421|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.42|
|[[:human genes:p:psmd1|PSMD1]]|0.42|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.42|
|[[:human genes:d:dhx38|DHX38]]|0.42|
|[[:human genes:t:twistnb|TWISTNB]]|0.419|
|[[:human genes:r:rpa2|RPA2]]|0.418|
|[[:human genes:r:rrp15|RRP15]]|0.417|
|[[:human genes:c:ccdc94|CCDC94]]|0.417|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.416|
|[[:human genes:d:dido1|DIDO1]]|0.416|
|[[:human genes:e:exd1|EXD1]]|0.415|
|[[:human genes:p:psmb2|PSMB2]]|0.415|
|[[:human genes:c:c14orf93|C14orf93]]|0.414|
|[[:human genes:s:setd1a|SETD1A]]|0.413|
|[[:human genes:b:bysl|BYSL]]|0.412|
|[[:human genes:o:orc6|ORC6]]|0.412|
|[[:human genes:c:cdc6|CDC6]]|0.411|
|[[:human genes:p:pola2|POLA2]]|0.41|
|[[:human genes:a:akirin2|AKIRIN2]]|0.41|
|[[:human genes:a:aqr|AQR]]|0.409|
|[[:human genes:v:vasn|VASN]]|0.409|
|[[:human genes:r:rpl34|RPL34]]|0.407|
|[[:human genes:i:ints6|INTS6]]|0.407|
|[[:human genes:r:rrp7a|RRP7A]]|0.406|
|[[:human genes:c:copa|COPA]]|0.404|
|[[:human genes:c:ccna2|CCNA2]]|0.404|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.403|
|[[:human genes:d:dand5|DAND5]]|0.403|
|[[:human genes:l:lrr1|LRR1]]|0.403|
|[[:human genes:m:mdm2|MDM2]]|0.402|
|[[:human genes:a:apc2|APC2]]|0.402|
|[[:human genes:e:eif4a3|EIF4A3]]|0.402|
|[[:human genes:n:nol10|NOL10]]|0.401|
|[[:human genes:w:wdr87|WDR87]]|0.401|
|[[:human genes:n:nbpf10|NBPF10]]|0.4|
|[[:human genes:r:rbbp5|RBBP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 535/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|23/26|
|bone|20/26|
|breast|24/30|
|central nervous system|36/49|
|cervix|1/4|
|colorectal|13/17|
|esophagus|7/11|
|fibroblast|0/1|
|gastric|13/14|
|kidney|12/18|
|liver|11/19|
|lung|52/72|
|lymphocyte|15/16|
|ovary|20/25|
|pancreas|14/22|
|peripheral nervous system|11/15|
|plasma cell|7/12|
|prostate|1/1|
|skin|16/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|24/28|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1613
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF113A Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>