======= RNF165 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF165
  * **<color #00a2e8>Official Name</color>**: ring finger protein 165
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=494470|494470]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZSG1|Q6ZSG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF165&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF165|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. {ECO:0000250|UniProtKB:E9QAU8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-rbx1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|innervation|
|motor neuron axon guidance|
|positive regulation of BMP signaling pathway|
|multicellular organism aging|
|forelimb morphogenesis|
|nerve development|
|regulation of BMP signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|limb morphogenesis|
|appendage morphogenesis|
|limb development|
|appendage development|
|ubiquitin protein ligase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|axon guidance|
|neuron projection guidance|
|regulation of cellular response to growth factor stimulus|
|aging|
|protein polyubiquitination|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|protein-containing complex|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|cell morphogenesis|
|protein modification by small protein conjugation|
|neuron development|
|cellular component morphogenesis|
|zinc ion binding|
|protein modification by small protein conjugation or removal|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|organic substance catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.25|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.98|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.94|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.74|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.75|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.77|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF165 Expression in NALM6 Cells: 2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>