======= RNF214 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF214
  * **<color #00a2e8>Official Name</color>**: ring finger protein 214
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=257160|257160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8ND24|Q8ND24]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF214&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF214|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-protein transferase activity|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.15|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.74|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.8|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.81|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.91|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.92|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.94|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.97|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.04|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.15|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.16|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.27|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dohh|DOHH]]|0.423|
|[[:human genes:b:bak1|BAK1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18234
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF214 Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>