======= ROBO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROBO2
  * **<color #00a2e8>Official Name</color>**: roundabout guidance receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6092|6092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCK4|Q9HCK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROBO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROBO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602431|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|ig|
|fn3|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of negative chemotaxis|
|apoptotic process involved in luteolysis|
|regulation of negative chemotaxis|
|positive regulation of Notch signaling pathway involved in heart induction|
|regulation of Notch signaling pathway involved in heart induction|
|axon midline choice point recognition|
|positive regulation of heart induction|
|axon choice point recognition|
|regulation of heart induction|
|luteolysis|
|negative regulation of synapse assembly|
|axon guidance receptor activity|
|olfactory bulb interneuron development|
|olfactory bulb interneuron differentiation|
|axolemma|
|pulmonary valve morphogenesis|
|retinal ganglion cell axon guidance|
|endocardial cushion formation|
|pulmonary valve development|
|negative regulation of synapse organization|
|apoptotic process involved in development|
|outflow tract septum morphogenesis|
|aortic valve morphogenesis|
|forebrain neuron development|
|aortic valve development|
|olfactory bulb development|
|olfactory lobe development|
|endocardial cushion morphogenesis|
|regulation of animal organ formation|
|semi-lunar valve development|
|regulation of heart morphogenesis|
|ventricular septum morphogenesis|
|endocardial cushion development|
|ovulation cycle process|
|neuron recognition|
|mesenchyme morphogenesis|
|aorta development|
|forebrain neuron differentiation|
|positive regulation of Notch signaling pathway|
|heart valve morphogenesis|
|negative regulation of chemotaxis|
|heart valve development|
|forebrain generation of neurons|
|ovulation cycle|
|ventricular septum development|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|central nervous system neuron development|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|ureteric bud development|
|positive regulation of axonogenesis|
|artery development|
|mesonephric epithelium development|
|mesonephric tubule development|
|female gonad development|
|mesonephros development|
|development of primary female sexual characteristics|
|regulation of Notch signaling pathway|
|regulation of synapse assembly|
|female sex differentiation|
|spinal cord development|
|cardiac septum development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|positive regulation of cell morphogenesis involved in differentiation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cardiac chamber development|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|gonad development|
|regulation of chemotaxis|
|development of primary sexual characteristics|
|regulation of synapse organization|
|mesenchyme development|
|regulation of synapse structure or activity|
|cell recognition|
|heart morphogenesis|
|telencephalon development|
|regulation of animal organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|kidney development|
|rhythmic process|
|positive regulation of neuron projection development|
|renal system development|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|urogenital system development|
|negative regulation of locomotion|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|forebrain development|
|axon development|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|cell surface|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16496
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROBO2 Expression in NALM6 Cells: 0.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>