======= RPIA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPIA
  * **<color #00a2e8>Official Name</color>**: ribose 5-phosphate isomerase A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22934|22934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49247|P49247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPIA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPIA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rib 5-P isom A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribose-5-phosphate isomerase activity|
|D-ribose metabolic process|
|pentose-phosphate shunt, non-oxidative branch|
|pentose-phosphate shunt|
|monosaccharide binding|
|pentose metabolic process|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|monosaccharide metabolic process|
|ribose phosphate metabolic process|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|intracellular membrane-bounded organelle|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp303|39°C R06 exp303]]|-2|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.7|
|[[:results:exp539|42°C R08 exp539]]|1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.88|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.92|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.02|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.18|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.55|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atxn10|ATXN10]]|0.602|
|[[:human genes:v:vezt|VEZT]]|0.601|
|[[:human genes:t:ten1|TEN1]]|0.597|
|[[:human genes:t:thg1l|THG1L]]|0.592|
|[[:human genes:p:pmm2|PMM2]]|0.588|
|[[:human genes:d:dnlz|DNLZ]]|0.581|
|[[:human genes:d:ddx39a|DDX39A]]|0.576|
|[[:human genes:t:trmt61a|TRMT61A]]|0.571|
|[[:human genes:f:fh|FH]]|0.57|
|[[:human genes:l:lsm10|LSM10]]|0.569|
|[[:human genes:g:gemin8|GEMIN8]]|0.567|
|[[:human genes:p:ppcs|PPCS]]|0.564|
|[[:human genes:t:triap1|TRIAP1]]|0.564|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.56|
|[[:human genes:s:srp14|SRP14]]|0.552|
|[[:human genes:g:gemin6|GEMIN6]]|0.55|
|[[:human genes:a:atic|ATIC]]|0.546|
|[[:human genes:c:chchd4|CHCHD4]]|0.546|
|[[:human genes:r:rpp21|RPP21]]|0.545|
|[[:human genes:g:gemin7|GEMIN7]]|0.543|
|[[:human genes:s:slc25a26|SLC25A26]]|0.542|
|[[:human genes:d:dhrsx|DHRSX]]|0.542|
|[[:human genes:a:alg1|ALG1]]|0.542|
|[[:human genes:d:dpagt1|DPAGT1]]|0.537|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.536|
|[[:human genes:g:gatc|GATC]]|0.533|
|[[:human genes:r:rpe|RPE]]|0.533|
|[[:human genes:p:pgm3|PGM3]]|0.526|
|[[:human genes:u:uap1|UAP1]]|0.515|
|[[:human genes:s:srd5a3|SRD5A3]]|0.514|
|[[:human genes:m:mrpl21|MRPL21]]|0.513|
|[[:human genes:c:c15orf41|C15orf41]]|0.512|
|[[:human genes:m:mrps14|MRPS14]]|0.51|
|[[:human genes:t:tpk1|TPK1]]|0.508|
|[[:human genes:r:romo1|ROMO1]]|0.507|
|[[:human genes:p:pmvk|PMVK]]|0.507|
|[[:human genes:t:trmt6|TRMT6]]|0.507|
|[[:human genes:r:rpusd4|RPUSD4]]|0.504|
|[[:human genes:s:sco2|SCO2]]|0.499|
|[[:human genes:t:tmem242|TMEM242]]|0.498|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.496|
|[[:human genes:a:adsl|ADSL]]|0.495|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.494|
|[[:human genes:m:mrps34|MRPS34]]|0.494|
|[[:human genes:t:tamm41|TAMM41]]|0.493|
|[[:human genes:p:ppcdc|PPCDC]]|0.493|
|[[:human genes:m:mrps5|MRPS5]]|0.493|
|[[:human genes:y:yars2|YARS2]]|0.492|
|[[:human genes:t:ttc4|TTC4]]|0.491|
|[[:human genes:t:tars2|TARS2]]|0.489|
|[[:human genes:s:selrc1|SELRC1]]|0.489|
|[[:human genes:u:uhrf1|UHRF1]]|0.489|
|[[:human genes:t:tsen54|TSEN54]]|0.484|
|[[:human genes:m:mrps33|MRPS33]]|0.484|
|[[:human genes:m:mrpl23|MRPL23]]|0.484|
|[[:human genes:d:dolk|DOLK]]|0.483|
|[[:human genes:r:rabggtb|RABGGTB]]|0.482|
|[[:human genes:d:dohh|DOHH]]|0.482|
|[[:human genes:b:bcs1l|BCS1L]]|0.482|
|[[:human genes:t:tbcb|TBCB]]|0.481|
|[[:human genes:r:rbfa|RBFA]]|0.481|
|[[:human genes:z:zrsr2|ZRSR2]]|0.48|
|[[:human genes:r:rft1|RFT1]]|0.48|
|[[:human genes:p:ppa2|PPA2]]|0.478|
|[[:human genes:c:c17orf89|C17orf89]]|0.476|
|[[:human genes:p:pdss1|PDSS1]]|0.476|
|[[:human genes:g:gmppb|GMPPB]]|0.475|
|[[:human genes:d:dap3|DAP3]]|0.475|
|[[:human genes:p:pars2|PARS2]]|0.475|
|[[:human genes:u:urm1|URM1]]|0.473|
|[[:human genes:d:dars2|DARS2]]|0.473|
|[[:human genes:m:mrps2|MRPS2]]|0.472|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.467|
|[[:human genes:a:alg8|ALG8]]|0.467|
|[[:human genes:r:rfk|RFK]]|0.462|
|[[:human genes:m:mrps16|MRPS16]]|0.462|
|[[:human genes:m:mrpl53|MRPL53]]|0.462|
|[[:human genes:s:sars2|SARS2]]|0.462|
|[[:human genes:m:mrps21|MRPS21]]|0.461|
|[[:human genes:t:trmt10a|TRMT10A]]|0.461|
|[[:human genes:p:pgs1|PGS1]]|0.461|
|[[:human genes:c:cep57|CEP57]]|0.459|
|[[:human genes:m:mrps6|MRPS6]]|0.458|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.458|
|[[:human genes:d:dr1|DR1]]|0.457|
|[[:human genes:n:n6amt1|N6AMT1]]|0.456|
|[[:human genes:c:ctc1|CTC1]]|0.456|
|[[:human genes:c:c1d|C1D]]|0.455|
|[[:human genes:e:elac2|ELAC2]]|0.455|
|[[:human genes:a:alg6|ALG6]]|0.454|
|[[:human genes:m:mrps18a|MRPS18A]]|0.452|
|[[:human genes:a:atp5d|ATP5D]]|0.451|
|[[:human genes:e:ears2|EARS2]]|0.451|
|[[:human genes:a:alg13|ALG13]]|0.45|
|[[:human genes:f:fkbpl|FKBPL]]|0.449|
|[[:human genes:p:ppp6c|PPP6C]]|0.448|
|[[:human genes:c:c10orf2|C10orf2]]|0.446|
|[[:human genes:k:kctd5|KCTD5]]|0.445|
|[[:human genes:p:ptar1|PTAR1]]|0.444|
|[[:human genes:m:mrpl15|MRPL15]]|0.444|
|[[:human genes:t:tkt|TKT]]|0.442|
|[[:human genes:p:pgk1|PGK1]]|0.441|
|[[:human genes:s:ssb|SSB]]|0.439|
|[[:human genes:f:fastkd5|FASTKD5]]|0.439|
|[[:human genes:m:mbtps2|MBTPS2]]|0.438|
|[[:human genes:s:slc25a19|SLC25A19]]|0.438|
|[[:human genes:p:polg|POLG]]|0.438|
|[[:human genes:c:cox16|COX16]]|0.437|
|[[:human genes:w:wdr92|WDR92]]|0.437|
|[[:human genes:e:elp2|ELP2]]|0.435|
|[[:human genes:u:utp23|UTP23]]|0.435|
|[[:human genes:u:uqcr10|UQCR10]]|0.433|
|[[:human genes:g:gfm1|GFM1]]|0.433|
|[[:human genes:g:gfpt1|GFPT1]]|0.431|
|[[:human genes:q:qrsl1|QRSL1]]|0.43|
|[[:human genes:e:ercc2|ERCC2]]|0.429|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.427|
|[[:human genes:m:mrps11|MRPS11]]|0.427|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.425|
|[[:human genes:e:eno1|ENO1]]|0.425|
|[[:human genes:t:txnrd1|TXNRD1]]|0.425|
|[[:human genes:r:rtcb|RTCB]]|0.424|
|[[:human genes:f:fen1|FEN1]]|0.424|
|[[:human genes:p:ppa1|PPA1]]|0.423|
|[[:human genes:h:hars2|HARS2]]|0.422|
|[[:human genes:t:trnt1|TRNT1]]|0.421|
|[[:human genes:t:tube1|TUBE1]]|0.421|
|[[:human genes:f:fnta|FNTA]]|0.42|
|[[:human genes:t:tufm|TUFM]]|0.42|
|[[:human genes:t:timm8b|TIMM8B]]|0.419|
|[[:human genes:n:nars2|NARS2]]|0.418|
|[[:human genes:k:kdsr|KDSR]]|0.417|
|[[:human genes:c:cox5a|COX5A]]|0.415|
|[[:human genes:o:oraov1|ORAOV1]]|0.414|
|[[:human genes:e:eif3f|EIF3F]]|0.414|
|[[:human genes:c:crls1|CRLS1]]|0.412|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:n:ndufb11|NDUFB11]]|0.41|
|[[:human genes:m:msto1|MSTO1]]|0.41|
|[[:human genes:t:taf1a|TAF1A]]|0.409|
|[[:human genes:m:mtg2|MTG2]]|0.408|
|[[:human genes:p:pggt1b|PGGT1B]]|0.407|
|[[:human genes:g:gemin4|GEMIN4]]|0.407|
|[[:human genes:c:cxorf56|CXorf56]]|0.407|
|[[:human genes:h:hccs|HCCS]]|0.406|
|[[:human genes:a:atp5h|ATP5H]]|0.406|
|[[:human genes:m:mrps24|MRPS24]]|0.405|
|[[:human genes:t:tefm|TEFM]]|0.404|
|[[:human genes:t:tubd1|TUBD1]]|0.403|
|[[:human genes:p:ppp4c|PPP4C]]|0.401|
|[[:human genes:r:rbbp4|RBBP4]]|0.401|
|[[:human genes:a:atp5a1|ATP5A1]]|0.401|
|[[:human genes:n:ndufb5|NDUFB5]]|0.401|
|[[:human genes:u:uxt|UXT]]|0.401|
|[[:human genes:d:ddx1|DDX1]]|0.4|
|[[:human genes:n:ndufb6|NDUFB6]]|0.4|
|[[:human genes:l:lars2|LARS2]]|0.4|
|[[:human genes:g:gfm2|GFM2]]|0.4|
|[[:human genes:d:ddx20|DDX20]]|0.4|
|[[:human genes:m:mrps9|MRPS9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4224
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPIA Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>