======= RPL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL10
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6134|6134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27635|P27635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312173|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic brain development|
|translation regulator activity|
|smooth endoplasmic reticulum|
|ribosomal large subunit assembly|
|ribosome assembly|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|embryonic organ development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|protein-containing complex|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|embryo development|
|negative regulation of cell death|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.02|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.83|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.75|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.74|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.75|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.79|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.81|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.92|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.97|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.32|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.35|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.62|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 663/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/26|
|bone|25/26|
|breast|28/30|
|central nervous system|47/49|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|17/18|
|liver|17/19|
|lung|69/72|
|lymphocyte|15/16|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|11/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|24/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 212
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL10 Expression in NALM6 Cells: 9.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>