======= RPL12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL12
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6136|6136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30050|P30050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds directly to 26S ribosomal RNA. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L11|
|Ribosomal L11 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|large ribosomal subunit rRNA binding|
|large ribosomal subunit|
|ribosomal large subunit assembly|
|rRNA binding|
|ribosome assembly|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.75|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.7|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.72|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.74|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.75|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.78|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.8|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.81|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.85|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.86|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.87|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.01|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.11|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.19|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.45|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.48|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aamp|AAMP]]|0.464|
|[[:human genes:r:rpl35|RPL35]]|0.442|
|[[:human genes:p:prim1|PRIM1]]|0.439|
|[[:human genes:r:rps2|RPS2]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.424|
|[[:human genes:a:ankle2|ANKLE2]]|0.414|
|[[:human genes:s:supt5h|SUPT5H]]|0.412|
|[[:human genes:c:chd4|CHD4]]|0.401|
|[[:human genes:p:polr2j3|POLR2J3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 506
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL12 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>