======= RPN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPN1
  * **<color #00a2e8>Official Name</color>**: ribophorin I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6184|6184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04843|P04843]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08, ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribophorin I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|rough endoplasmic reticulum|
|protein N-linked glycosylation|
|melanosome|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.1|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddost|DDOST]]|0.602|
|[[:human genes:d:dad1|DAD1]]|0.593|
|[[:human genes:g:gmppb|GMPPB]]|0.582|
|[[:human genes:p:pam16|PAM16]]|0.561|
|[[:human genes:a:alg2|ALG2]]|0.551|
|[[:human genes:r:rnmt|RNMT]]|0.548|
|[[:human genes:h:hars|HARS]]|0.54|
|[[:human genes:g:gnb1l|GNB1L]]|0.527|
|[[:human genes:r:rptor|RPTOR]]|0.523|
|[[:human genes:p:pmm2|PMM2]]|0.512|
|[[:human genes:e:exoc4|EXOC4]]|0.512|
|[[:human genes:h:hspd1|HSPD1]]|0.509|
|[[:human genes:d:dohh|DOHH]]|0.508|
|[[:human genes:m:mtor|MTOR]]|0.508|
|[[:human genes:a:alg13|ALG13]]|0.505|
|[[:human genes:g:gfpt1|GFPT1]]|0.502|
|[[:human genes:t:thg1l|THG1L]]|0.501|
|[[:human genes:d:dpagt1|DPAGT1]]|0.5|
|[[:human genes:r:rtcb|RTCB]]|0.496|
|[[:human genes:u:uap1|UAP1]]|0.489|
|[[:human genes:a:aars|AARS]]|0.486|
|[[:human genes:a:alg1|ALG1]]|0.485|
|[[:human genes:t:triap1|TRIAP1]]|0.483|
|[[:human genes:t:tmem258|TMEM258]]|0.477|
|[[:human genes:r:rpn2|RPN2]]|0.472|
|[[:human genes:s:slc35b1|SLC35B1]]|0.47|
|[[:human genes:m:med16|MED16]]|0.468|
|[[:human genes:c:crcp|CRCP]]|0.465|
|[[:human genes:n:nars|NARS]]|0.463|
|[[:human genes:e:exoc3|EXOC3]]|0.463|
|[[:human genes:p:pdpk1|PDPK1]]|0.46|
|[[:human genes:t:telo2|TELO2]]|0.458|
|[[:human genes:e:eprs|EPRS]]|0.457|
|[[:human genes:b:bap1|BAP1]]|0.456|
|[[:human genes:s:spcs2|SPCS2]]|0.456|
|[[:human genes:o:oraov1|ORAOV1]]|0.455|
|[[:human genes:o:osgep|OSGEP]]|0.455|
|[[:human genes:a:abcb7|ABCB7]]|0.455|
|[[:human genes:t:tti2|TTI2]]|0.453|
|[[:human genes:c:cbfb|CBFB]]|0.453|
|[[:human genes:c:casp9|CASP9]]|0.453|
|[[:human genes:d:dhps|DHPS]]|0.451|
|[[:human genes:r:romo1|ROMO1]]|0.444|
|[[:human genes:h:hccs|HCCS]]|0.444|
|[[:human genes:m:meaf6|MEAF6]]|0.444|
|[[:human genes:a:apaf1|APAF1]]|0.443|
|[[:human genes:p:polr3h|POLR3H]]|0.443|
|[[:human genes:p:pelo|PELO]]|0.442|
|[[:human genes:c:ccdc101|CCDC101]]|0.439|
|[[:human genes:p:pisd|PISD]]|0.438|
|[[:human genes:s:srp72|SRP72]]|0.438|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.436|
|[[:human genes:p:plaa|PLAA]]|0.432|
|[[:human genes:z:znf259|ZNF259]]|0.428|
|[[:human genes:t:tsen54|TSEN54]]|0.427|
|[[:human genes:t:taz|TAZ]]|0.427|
|[[:human genes:d:diablo|DIABLO]]|0.427|
|[[:human genes:c:csnk2b|CSNK2B]]|0.426|
|[[:human genes:e:eif4e|EIF4E]]|0.425|
|[[:human genes:a:alg5|ALG5]]|0.421|
|[[:human genes:y:yars|YARS]]|0.42|
|[[:human genes:a:atp2a2|ATP2A2]]|0.415|
|[[:human genes:w:wdr24|WDR24]]|0.415|
|[[:human genes:t:trnt1|TRNT1]]|0.414|
|[[:human genes:o:oip5|OIP5]]|0.412|
|[[:human genes:p:polr3b|POLR3B]]|0.41|
|[[:human genes:u:uxt|UXT]]|0.41|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.408|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.407|
|[[:human genes:u:utp23|UTP23]]|0.407|
|[[:human genes:d:ddx20|DDX20]]|0.406|
|[[:human genes:n:nsd1|NSD1]]|0.405|
|[[:human genes:t:tamm41|TAMM41]]|0.403|
|[[:human genes:s:sec61g|SEC61G]]|0.403|
|[[:human genes:m:mllt1|MLLT1]]|0.402|
|[[:human genes:b:bak1|BAK1]]|0.402|
|[[:human genes:v:vmp1|VMP1]]|0.401|
|[[:human genes:v:vdac2|VDAC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 669/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|24/26|
|breast|26/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|64/75|
|lymphocyte|14/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|11/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPN1 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>