======= RPS28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS28
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6234|6234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62857|P62857]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603685|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S28e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of rough endoplasmic reticulum membrane|
|small ribosomal subunit|
|ribosomal small subunit assembly|
|polysomal ribosome|
|cytosolic small ribosomal subunit|
|maturation of SSU-rRNA|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.23|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.22|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.21|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.04|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.92|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.85|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.7|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.75|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.78|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.79|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.82|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.82|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.83|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.83|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.87|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.88|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.91|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.96|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.02|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.13|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.13|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.17|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.39|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.52|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.59|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd11|PSMD11]]|0.545|
|[[:human genes:r:rps5|RPS5]]|0.538|
|[[:human genes:p:psmd1|PSMD1]]|0.535|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.53|
|[[:human genes:r:rps12|RPS12]]|0.528|
|[[:human genes:r:rbbp5|RBBP5]]|0.517|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.512|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.511|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.511|
|[[:human genes:z:zfand5|ZFAND5]]|0.51|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.51|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.508|
|[[:human genes:n:nup133|NUP133]]|0.506|
|[[:human genes:c:cbwd5|CBWD5]]|0.501|
|[[:human genes:p:psmc1|PSMC1]]|0.5|
|[[:human genes:v:vasn|VASN]]|0.499|
|[[:human genes:p:ppfia4|PPFIA4]]|0.497|
|[[:human genes:n:nop16|NOP16]]|0.495|
|[[:human genes:p:psmb1|PSMB1]]|0.493|
|[[:human genes:r:rps9|RPS9]]|0.491|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.49|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.489|
|[[:human genes:a:akirin2|AKIRIN2]]|0.488|
|[[:human genes:s:scaf1|SCAF1]]|0.487|
|[[:human genes:c:cope|COPE]]|0.486|
|[[:human genes:n:nupl1|NUPL1]]|0.483|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.479|
|[[:human genes:t:twistnb|TWISTNB]]|0.478|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.478|
|[[:human genes:c:cbwd3|CBWD3]]|0.477|
|[[:human genes:r:rps11|RPS11]]|0.475|
|[[:human genes:r:rbm39|RBM39]]|0.474|
|[[:human genes:c:cdc73|CDC73]]|0.473|
|[[:human genes:r:rps2|RPS2]]|0.472|
|[[:human genes:p:psmb4|PSMB4]]|0.471|
|[[:human genes:r:rpl30|RPL30]]|0.47|
|[[:human genes:t:top1mt|TOP1MT]]|0.47|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.469|
|[[:human genes:t:tfip11|TFIP11]]|0.469|
|[[:human genes:u:utp20|UTP20]]|0.465|
|[[:human genes:a:ahctf1|AHCTF1]]|0.463|
|[[:human genes:c:cbwd6|CBWD6]]|0.462|
|[[:human genes:s:smg7|SMG7]]|0.461|
|[[:human genes:c:ckap5|CKAP5]]|0.46|
|[[:human genes:r:rps14|RPS14]]|0.457|
|[[:human genes:p:psma6|PSMA6]]|0.455|
|[[:human genes:d:ddtl|DDTL]]|0.452|
|[[:human genes:i:iscu|ISCU]]|0.451|
|[[:human genes:d:dtl|DTL]]|0.449|
|[[:human genes:h:hivep3|HIVEP3]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.448|
|[[:human genes:k:kif3c|KIF3C]]|0.447|
|[[:human genes:r:rps27a|RPS27A]]|0.446|
|[[:human genes:z:znf106|ZNF106]]|0.446|
|[[:human genes:n:nol10|NOL10]]|0.443|
|[[:human genes:r:rnf4|RNF4]]|0.443|
|[[:human genes:t:terf2|TERF2]]|0.442|
|[[:human genes:r:rps16|RPS16]]|0.442|
|[[:human genes:r:rpl14|RPL14]]|0.442|
|[[:human genes:p:psma7|PSMA7]]|0.441|
|[[:human genes:r:riok2|RIOK2]]|0.44|
|[[:human genes:r:rps3|RPS3]]|0.44|
|[[:human genes:z:znf830|ZNF830]]|0.439|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.439|
|[[:human genes:c:ccna2|CCNA2]]|0.436|
|[[:human genes:p:psmd13|PSMD13]]|0.435|
|[[:human genes:n:nfatc4|NFATC4]]|0.434|
|[[:human genes:w:wdr43|WDR43]]|0.432|
|[[:human genes:s:snrpa1|SNRPA1]]|0.432|
|[[:human genes:p:psmc5|PSMC5]]|0.432|
|[[:human genes:c:chd4|CHD4]]|0.431|
|[[:human genes:p:psma1|PSMA1]]|0.431|
|[[:human genes:r:rps7|RPS7]]|0.43|
|[[:human genes:h:hap1|HAP1]]|0.428|
|[[:human genes:c:chaf1a|CHAF1A]]|0.427|
|[[:human genes:r:rrn3|RRN3]]|0.427|
|[[:human genes:p:pola1|POLA1]]|0.426|
|[[:human genes:r:rpl38|RPL38]]|0.426|
|[[:human genes:c:c14orf93|C14orf93]]|0.425|
|[[:human genes:p:psmd6|PSMD6]]|0.425|
|[[:human genes:o:orc6|ORC6]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.424|
|[[:human genes:n:nbpf16|NBPF16]]|0.424|
|[[:human genes:s:ssh2|SSH2]]|0.423|
|[[:human genes:m:myb|MYB]]|0.423|
|[[:human genes:t:tceb3c|TCEB3C]]|0.423|
|[[:human genes:o:ogfr|OGFR]]|0.421|
|[[:human genes:n:nop14|NOP14]]|0.421|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.421|
|[[:human genes:r:rps3a|RPS3A]]|0.42|
|[[:human genes:f:fam160a1|FAM160A1]]|0.419|
|[[:human genes:r:rpl35|RPL35]]|0.419|
|[[:human genes:c:cdc45|CDC45]]|0.419|
|[[:human genes:s:supt6h|SUPT6H]]|0.419|
|[[:human genes:p:psmd3|PSMD3]]|0.419|
|[[:human genes:p:psmc6|PSMC6]]|0.419|
|[[:human genes:g:glcci1|GLCCI1]]|0.417|
|[[:human genes:r:ranbp2|RANBP2]]|0.417|
|[[:human genes:x:xylt2|XYLT2]]|0.417|
|[[:human genes:p:psmc4|PSMC4]]|0.416|
|[[:human genes:c:cnpy3|CNPY3]]|0.415|
|[[:human genes:o:or10g3|OR10G3]]|0.415|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:a:acsf2|ACSF2]]|0.415|
|[[:human genes:f:fbxw9|FBXW9]]|0.415|
|[[:human genes:s:syt9|SYT9]]|0.414|
|[[:human genes:n:ndc1|NDC1]]|0.414|
|[[:human genes:r:rffl|RFFL]]|0.413|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.412|
|[[:human genes:l:lrr1|LRR1]]|0.412|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.411|
|[[:human genes:s:s1pr4|S1PR4]]|0.411|
|[[:human genes:d:dnm2|DNM2]]|0.411|
|[[:human genes:m:mt1e|MT1E]]|0.41|
|[[:human genes:s:shfm1|SHFM1]]|0.409|
|[[:human genes:r:rps6|RPS6]]|0.408|
|[[:human genes:r:rpl34|RPL34]]|0.408|
|[[:human genes:r:rfc1|RFC1]]|0.407|
|[[:human genes:p:prpf8|PRPF8]]|0.407|
|[[:human genes:p:pola2|POLA2]]|0.406|
|[[:human genes:p:pwp2|PWP2]]|0.406|
|[[:human genes:p:psmb2|PSMB2]]|0.406|
|[[:human genes:o:orc1|ORC1]]|0.405|
|[[:human genes:t:traip|TRAIP]]|0.405|
|[[:human genes:r:rab40al|RAB40AL]]|0.405|
|[[:human genes:c:ctdp1|CTDP1]]|0.404|
|[[:human genes:p:paf1|PAF1]]|0.404|
|[[:human genes:c:cwc22|CWC22]]|0.404|
|[[:human genes:t:tcf3|TCF3]]|0.403|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.403|
|[[:human genes:c:ctr9|CTR9]]|0.403|
|[[:human genes:a:acd|ACD]]|0.403|
|[[:human genes:g:golga8o|GOLGA8O]]|0.403|
|[[:human genes:s:stil|STIL]]|0.402|
|[[:human genes:r:rfxank|RFXANK]]|0.402|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:a:arcn1|ARCN1]]|0.401|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.401|
|[[:human genes:p:plcg2|PLCG2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 727/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 126
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS28 Expression in NALM6 Cells: 8.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>