======= RPS6KB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS6KB1
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S6 kinase B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6198|6198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23443|P23443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS6KB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS6KB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608938|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti- apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1- 2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. {ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:23429703}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase C|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal protein S6 kinase activity|
|lipid import into cell|
|long-chain fatty acid import into cell|
|TOR signaling|
|protein serine/threonine/tyrosine kinase activity|
|positive regulation of translational initiation|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|long-chain fatty acid transport|
|regulation of insulin receptor signaling pathway|
|phosphatidylinositol-mediated signaling|
|regulation of cellular response to insulin stimulus|
|fatty acid transport|
|inositol lipid-mediated signaling|
|regulation of translational initiation|
|kinase activity|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|positive regulation of translation|
|monocarboxylic acid transport|
|positive regulation of mitotic cell cycle|
|positive regulation of cellular amide metabolic process|
|cellular response to insulin stimulus|
|mitochondrial outer membrane|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|response to insulin|
|protein kinase activity|
|cellular response to peptide hormone stimulus|
|synapse|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|neuron projection|
|lipid localization|
|cellular response to peptide|
|regulation of translation|
|protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|organic anion transport|
|response to peptide|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|response to growth factor|
|cell junction|
|anion transport|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|import into cell|
|mitotic cell cycle|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|apoptotic process|
|protein phosphorylation|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif1ax|EIF1AX]]|0.44|
|[[:human genes:r:rptor|RPTOR]]|0.438|
|[[:human genes:x:xpo6|XPO6]]|0.434|
|[[:human genes:w:wsb1|WSB1]]|0.432|
|[[:human genes:m:mllt1|MLLT1]]|0.416|
|[[:human genes:u:ube2j1|UBE2J1]]|0.407|
|[[:human genes:w:wdr24|WDR24]]|0.402|
|[[:human genes:d:dnajc3|DNAJC3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6014
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS6KB1 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>