======= RPS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS9
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6203|6203]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46781|P46781]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603631|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S4|
|S4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of translational fidelity|
|translation regulator activity|
|regulation of translational fidelity|
|rRNA binding|
|ribosome|
|cytosolic small ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|positive regulation of translation|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|synapse|
|ribosome biogenesis|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.28|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.95|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.7|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.7|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.7|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.72|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.75|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.76|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.76|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.76|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.79|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.84|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.89|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.94|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.06|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.08|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.08|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.23|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.27|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.28|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.63|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.75|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.79|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps3a|RPS3A]]|0.548|
|[[:human genes:c:cope|COPE]]|0.527|
|[[:human genes:p:psmb4|PSMB4]]|0.523|
|[[:human genes:r:rpl35|RPL35]]|0.52|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.512|
|[[:human genes:v:vasn|VASN]]|0.512|
|[[:human genes:n:npipb5|NPIPB5]]|0.508|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.507|
|[[:human genes:p:psmd1|PSMD1]]|0.505|
|[[:human genes:p:psma7|PSMA7]]|0.494|
|[[:human genes:c:ctr9|CTR9]]|0.494|
|[[:human genes:p:paf1|PAF1]]|0.493|
|[[:human genes:r:rps28|RPS28]]|0.491|
|[[:human genes:g:golga8o|GOLGA8O]]|0.491|
|[[:human genes:c:ckap5|CKAP5]]|0.49|
|[[:human genes:c:cep192|CEP192]]|0.49|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.49|
|[[:human genes:t:tceb3c|TCEB3C]]|0.487|
|[[:human genes:s:snrpa1|SNRPA1]]|0.484|
|[[:human genes:s:s1pr4|S1PR4]]|0.481|
|[[:human genes:p:psmd2|PSMD2]]|0.475|
|[[:human genes:t:tfip11|TFIP11]]|0.474|
|[[:human genes:p:psmd3|PSMD3]]|0.474|
|[[:human genes:c:cdc73|CDC73]]|0.469|
|[[:human genes:p:psmc1|PSMC1]]|0.466|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.465|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.465|
|[[:human genes:n:nupl1|NUPL1]]|0.465|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.465|
|[[:human genes:p:pan3|PAN3]]|0.461|
|[[:human genes:r:rpsa|RPSA]]|0.46|
|[[:human genes:s:supt6h|SUPT6H]]|0.46|
|[[:human genes:c:ccna2|CCNA2]]|0.459|
|[[:human genes:d:ddx56|DDX56]]|0.458|
|[[:human genes:r:rps2|RPS2]]|0.457|
|[[:human genes:c:c14orf93|C14orf93]]|0.455|
|[[:human genes:a:ahctf1|AHCTF1]]|0.453|
|[[:human genes:f:fcn2|FCN2]]|0.453|
|[[:human genes:p:prim1|PRIM1]]|0.451|
|[[:human genes:u:upf1|UPF1]]|0.451|
|[[:human genes:n:nol10|NOL10]]|0.45|
|[[:human genes:r:rps7|RPS7]]|0.45|
|[[:human genes:p:pole|POLE]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.448|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.446|
|[[:human genes:r:rps5|RPS5]]|0.445|
|[[:human genes:p:psma6|PSMA6]]|0.445|
|[[:human genes:z:zfand5|ZFAND5]]|0.445|
|[[:human genes:e:esf1|ESF1]]|0.443|
|[[:human genes:t:trim52|TRIM52]]|0.443|
|[[:human genes:m:mt1e|MT1E]]|0.441|
|[[:human genes:t:twistnb|TWISTNB]]|0.441|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.44|
|[[:human genes:r:rps12|RPS12]]|0.44|
|[[:human genes:n:nop16|NOP16]]|0.44|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.439|
|[[:human genes:r:rad51|RAD51]]|0.438|
|[[:human genes:p:ppfia4|PPFIA4]]|0.437|
|[[:human genes:l:lrr1|LRR1]]|0.436|
|[[:human genes:s:sf3a1|SF3A1]]|0.436|
|[[:human genes:p:pola2|POLA2]]|0.435|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.433|
|[[:human genes:s:ssh2|SSH2]]|0.432|
|[[:human genes:p:psmb2|PSMB2]]|0.432|
|[[:human genes:r:rps16|RPS16]]|0.432|
|[[:human genes:s:srrm2|SRRM2]]|0.431|
|[[:human genes:h:hap1|HAP1]]|0.431|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.429|
|[[:human genes:a:acsf2|ACSF2]]|0.429|
|[[:human genes:p:pola1|POLA1]]|0.429|
|[[:human genes:n:npipb3|NPIPB3]]|0.429|
|[[:human genes:p:pcf11|PCF11]]|0.428|
|[[:human genes:p:psmb1|PSMB1]]|0.427|
|[[:human genes:a:ankle2|ANKLE2]]|0.425|
|[[:human genes:r:rrp15|RRP15]]|0.425|
|[[:human genes:r:rilpl1|RILPL1]]|0.425|
|[[:human genes:c:cgb2|CGB2]]|0.424|
|[[:human genes:k:krt78|KRT78]]|0.424|
|[[:human genes:s:scaf1|SCAF1]]|0.422|
|[[:human genes:c:copg1|COPG1]]|0.421|
|[[:human genes:s:sap30bp|SAP30BP]]|0.42|
|[[:human genes:t:tsr1|TSR1]]|0.42|
|[[:human genes:r:rps3|RPS3]]|0.42|
|[[:human genes:d:dnm2|DNM2]]|0.42|
|[[:human genes:g:golga8j|GOLGA8J]]|0.42|
|[[:human genes:s:sfpq|SFPQ]]|0.42|
|[[:human genes:i:ik|IK]]|0.418|
|[[:human genes:l:lad1|LAD1]]|0.418|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.418|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.416|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.416|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.415|
|[[:human genes:c:cdc6|CDC6]]|0.415|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.415|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.414|
|[[:human genes:n:nip7|NIP7]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:s:supt5h|SUPT5H]]|0.413|
|[[:human genes:r:rps20|RPS20]]|0.413|
|[[:human genes:c:cdca3|CDCA3]]|0.413|
|[[:human genes:e:eif4a3|EIF4A3]]|0.412|
|[[:human genes:b:bysl|BYSL]]|0.411|
|[[:human genes:n:npipb8|NPIPB8]]|0.411|
|[[:human genes:p:psmd11|PSMD11]]|0.41|
|[[:human genes:a:aamp|AAMP]]|0.409|
|[[:human genes:h:hivep3|HIVEP3]]|0.409|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.408|
|[[:human genes:n:nup85|NUP85]]|0.408|
|[[:human genes:t:taf15|TAF15]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:c:ccdc94|CCDC94]]|0.407|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.407|
|[[:human genes:p:pan2|PAN2]]|0.406|
|[[:human genes:c:cnot3|CNOT3]]|0.406|
|[[:human genes:r:rpl38|RPL38]]|0.406|
|[[:human genes:p:psmb3|PSMB3]]|0.406|
|[[:human genes:z:znf106|ZNF106]]|0.405|
|[[:human genes:r:rbm39|RBM39]]|0.405|
|[[:human genes:c:cbwd3|CBWD3]]|0.404|
|[[:human genes:d:dtl|DTL]]|0.404|
|[[:human genes:g:golga8r|GOLGA8R]]|0.403|
|[[:human genes:p:psmc6|PSMC6]]|0.403|
|[[:human genes:m:myb|MYB]]|0.402|
|[[:human genes:c:cwc22|CWC22]]|0.402|
|[[:human genes:r:rpl6|RPL6]]|0.402|
|[[:human genes:i:iscu|ISCU]]|0.4|
|[[:human genes:z:znf830|ZNF830]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS9 Expression in NALM6 Cells: 8.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>