======= RPTOR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPTOR
  * **<color #00a2e8>Official Name</color>**: regulatory associated protein of MTOR complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57521|57521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N122|Q8N122]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPTOR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPTOR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. {ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:23727834}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III type 2 promoter DNA binding|
|RNA polymerase III type 1 promoter DNA binding|
|TFIIIC-class transcription factor complex binding|
|RNA polymerase III type 3 promoter DNA binding|
|TORC1 complex|
|TORC1 signaling|
|protein serine/threonine kinase inhibitor activity|
|cellular response to leucine|
|positive regulation of transcription by RNA polymerase III|
|response to leucine|
|regulation of transcription by RNA polymerase III|
|protein kinase activator activity|
|TOR signaling|
|14-3-3 protein binding|
|positive regulation of peptidyl-threonine phosphorylation|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of TOR signaling|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of cell cycle G1/S phase transition|
|cytoplasmic stress granule|
|cellular response to amino acid stimulus|
|positive regulation of mitotic cell cycle phase transition|
|regulation of cellular response to heat|
|protein binding, bridging|
|positive regulation of cell cycle phase transition|
|positive regulation of endothelial cell proliferation|
|regulation of TOR signaling|
|positive regulation of peptidyl-serine phosphorylation|
|response to amino acid|
|regulation of endothelial cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|regulation of peptidyl-serine phosphorylation|
|cell cycle arrest|
|regulation of G1/S transition of mitotic cell cycle|
|cellular response to starvation|
|positive regulation of mitotic cell cycle|
|positive regulation of cell growth|
|regulation of cell cycle G1/S phase transition|
|regulation of macroautophagy|
|regulation of cell size|
|positive regulation of epithelial cell proliferation|
|response to starvation|
|cellular response to acid chemical|
|negative regulation of protein kinase activity|
|cellular response to nutrient levels|
|negative regulation of kinase activity|
|lysosome|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|negative regulation of transferase activity|
|positive regulation of cell cycle process|
|lysosomal membrane|
|activation of protein kinase activity|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|response to acid chemical|
|neuronal cell body|
|positive regulation of cell cycle|
|regulation of cellular component size|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|dendrite|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|response to nutrient levels|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|viral process|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.03|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.74|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.71|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.72|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.72|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.72|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.73|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.84|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.86|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.93|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.95|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.95|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.95|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.02|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.03|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.04|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.07|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.1|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.12|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.2|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.21|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.26|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.36|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.43|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.48|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.52|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.53|
|[[:results:exp539|42°C R08 exp539]]|2.57|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.63|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.68|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.73|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.79|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.79|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.83|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.83|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.86|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.93|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.99|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|3|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.16|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.17|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|3.21|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.38|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.41|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.45|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.53|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.53|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.54|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.68|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.84|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtor|MTOR]]|0.794|
|[[:human genes:w:wdr24|WDR24]]|0.787|
|[[:human genes:d:dohh|DOHH]]|0.756|
|[[:human genes:t:thg1l|THG1L]]|0.747|
|[[:human genes:r:rnmt|RNMT]]|0.711|
|[[:human genes:g:gmppb|GMPPB]]|0.699|
|[[:human genes:w:wdr59|WDR59]]|0.68|
|[[:human genes:e:eif4e|EIF4E]]|0.679|
|[[:human genes:a:alg1|ALG1]]|0.671|
|[[:human genes:c:ccdc101|CCDC101]]|0.664|
|[[:human genes:d:dpagt1|DPAGT1]]|0.663|
|[[:human genes:g:gfpt1|GFPT1]]|0.66|
|[[:human genes:t:tti2|TTI2]]|0.656|
|[[:human genes:h:hars|HARS]]|0.649|
|[[:human genes:r:rtcb|RTCB]]|0.648|
|[[:human genes:p:pmm2|PMM2]]|0.644|
|[[:human genes:c:cbfb|CBFB]]|0.643|
|[[:human genes:g:gnb1l|GNB1L]]|0.64|
|[[:human genes:v:vhl|VHL]]|0.64|
|[[:human genes:p:pelo|PELO]]|0.64|
|[[:human genes:u:uap1|UAP1]]|0.63|
|[[:human genes:m:meaf6|MEAF6]]|0.63|
|[[:human genes:t:triap1|TRIAP1]]|0.63|
|[[:human genes:b:bap1|BAP1]]|0.629|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.626|
|[[:human genes:e:eny2|ENY2]]|0.623|
|[[:human genes:n:nsd1|NSD1]]|0.619|
|[[:human genes:d:dhps|DHPS]]|0.615|
|[[:human genes:m:med16|MED16]]|0.614|
|[[:human genes:c:csnk2b|CSNK2B]]|0.611|
|[[:human genes:i:id3|ID3]]|0.606|
|[[:human genes:u:uhrf1|UHRF1]]|0.603|
|[[:human genes:u:ube2g2|UBE2G2]]|0.601|
|[[:human genes:m:mios|MIOS]]|0.599|
|[[:human genes:m:mllt1|MLLT1]]|0.596|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.594|
|[[:human genes:h:hspd1|HSPD1]]|0.594|
|[[:human genes:t:tmem41b|TMEM41B]]|0.592|
|[[:human genes:f:faf2|FAF2]]|0.592|
|[[:human genes:m:mlst8|MLST8]]|0.583|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.581|
|[[:human genes:p:plaa|PLAA]]|0.581|
|[[:human genes:e:exoc4|EXOC4]]|0.578|
|[[:human genes:t:trnt1|TRNT1]]|0.575|
|[[:human genes:m:med23|MED23]]|0.571|
|[[:human genes:c:casp9|CASP9]]|0.57|
|[[:human genes:s:srp14|SRP14]]|0.569|
|[[:human genes:a:aars|AARS]]|0.566|
|[[:human genes:t:tle4|TLE4]]|0.565|
|[[:human genes:a:alg13|ALG13]]|0.565|
|[[:human genes:d:dr1|DR1]]|0.565|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.565|
|[[:human genes:c:cct7|CCT7]]|0.564|
|[[:human genes:t:tti1|TTI1]]|0.563|
|[[:human genes:a:alg2|ALG2]]|0.563|
|[[:human genes:l:lsm11|LSM11]]|0.562|
|[[:human genes:a:adsl|ADSL]]|0.561|
|[[:human genes:t:trim28|TRIM28]]|0.561|
|[[:human genes:u:utp23|UTP23]]|0.555|
|[[:human genes:p:polr3b|POLR3B]]|0.553|
|[[:human genes:a:atp5j|ATP5J]]|0.553|
|[[:human genes:p:pam16|PAM16]]|0.551|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.549|
|[[:human genes:b:bak1|BAK1]]|0.549|
|[[:human genes:a:atxn10|ATXN10]]|0.549|
|[[:human genes:p:polr3h|POLR3H]]|0.548|
|[[:human genes:a:apaf1|APAF1]]|0.547|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.546|
|[[:human genes:r:rpp21|RPP21]]|0.546|
|[[:human genes:t:trmt5|TRMT5]]|0.544|
|[[:human genes:m:mapk14|MAPK14]]|0.543|
|[[:human genes:h:hccs|HCCS]]|0.541|
|[[:human genes:t:tbp|TBP]]|0.539|
|[[:human genes:n:nae1|NAE1]]|0.539|
|[[:human genes:r:rpe|RPE]]|0.537|
|[[:human genes:o:otud5|OTUD5]]|0.536|
|[[:human genes:t:telo2|TELO2]]|0.532|
|[[:human genes:a:alg5|ALG5]]|0.532|
|[[:human genes:n:nars|NARS]]|0.532|
|[[:human genes:s:serf2|SERF2]]|0.532|
|[[:human genes:d:dpf2|DPF2]]|0.531|
|[[:human genes:o:oraov1|ORAOV1]]|0.531|
|[[:human genes:s:seh1l|SEH1L]]|0.528|
|[[:human genes:r:romo1|ROMO1]]|0.528|
|[[:human genes:t:tsen54|TSEN54]]|0.527|
|[[:human genes:e:eprs|EPRS]]|0.526|
|[[:human genes:e:eif3f|EIF3F]]|0.525|
|[[:human genes:p:ppp4c|PPP4C]]|0.525|
|[[:human genes:t:trmt10a|TRMT10A]]|0.524|
|[[:human genes:r:rpn1|RPN1]]|0.523|
|[[:human genes:c:cmtr1|CMTR1]]|0.523|
|[[:human genes:s:ssbp2|SSBP2]]|0.523|
|[[:human genes:z:znf608|ZNF608]]|0.518|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.517|
|[[:human genes:v:vmp1|VMP1]]|0.515|
|[[:human genes:z:znf592|ZNF592]]|0.512|
|[[:human genes:o:osgep|OSGEP]]|0.509|
|[[:human genes:m:med4|MED4]]|0.509|
|[[:human genes:u:urm1|URM1]]|0.509|
|[[:human genes:d:dad1|DAD1]]|0.508|
|[[:human genes:p:ppcs|PPCS]]|0.506|
|[[:human genes:t:ten1|TEN1]]|0.505|
|[[:human genes:k:kdsr|KDSR]]|0.503|
|[[:human genes:c:cycs|CYCS]]|0.503|
|[[:human genes:m:mars|MARS]]|0.503|
|[[:human genes:u:ube2k|UBE2K]]|0.502|
|[[:human genes:p:pdap1|PDAP1]]|0.502|
|[[:human genes:a:atp5o|ATP5O]]|0.501|
|[[:human genes:s:ssb|SSB]]|0.501|
|[[:human genes:v:vrk1|VRK1]]|0.501|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.5|
|[[:human genes:y:yars|YARS]]|0.498|
|[[:human genes:t:thoc6|THOC6]]|0.496|
|[[:human genes:c:crcp|CRCP]]|0.496|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.494|
|[[:human genes:t:tsen34|TSEN34]]|0.492|
|[[:human genes:v:vezt|VEZT]]|0.491|
|[[:human genes:f:fbxo11|FBXO11]]|0.491|
|[[:human genes:t:timm13|TIMM13]]|0.49|
|[[:human genes:l:lsmd1|LSMD1]]|0.487|
|[[:human genes:u:ubqln1|UBQLN1]]|0.486|
|[[:human genes:t:taz|TAZ]]|0.484|
|[[:human genes:c:crls1|CRLS1]]|0.483|
|[[:human genes:v:vdac2|VDAC2]]|0.482|
|[[:human genes:t:ttc4|TTC4]]|0.481|
|[[:human genes:d:ddost|DDOST]]|0.481|
|[[:human genes:z:zzz3|ZZZ3]]|0.478|
|[[:human genes:h:haus8|HAUS8]]|0.478|
|[[:human genes:u:uba3|UBA3]]|0.474|
|[[:human genes:s:srp72|SRP72]]|0.472|
|[[:human genes:p:ppa2|PPA2]]|0.47|
|[[:human genes:d:diablo|DIABLO]]|0.469|
|[[:human genes:b:btaf1|BTAF1]]|0.468|
|[[:human genes:t:tamm41|TAMM41]]|0.468|
|[[:human genes:p:ppp6c|PPP6C]]|0.467|
|[[:human genes:d:dolk|DOLK]]|0.467|
|[[:human genes:t:tbcb|TBCB]]|0.467|
|[[:human genes:u:uxt|UXT]]|0.465|
|[[:human genes:m:march5|MARCH5]]|0.464|
|[[:human genes:s:sec62|SEC62]]|0.464|
|[[:human genes:s:slc35b1|SLC35B1]]|0.464|
|[[:human genes:m:metap2|METAP2]]|0.464|
|[[:human genes:a:atp5b|ATP5B]]|0.463|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.463|
|[[:human genes:t:trip12|TRIP12]]|0.463|
|[[:human genes:t:tgs1|TGS1]]|0.463|
|[[:human genes:t:tmed10|TMED10]]|0.463|
|[[:human genes:s:slc25a26|SLC25A26]]|0.46|
|[[:human genes:l:lmo2|LMO2]]|0.46|
|[[:human genes:o:oip5|OIP5]]|0.458|
|[[:human genes:e:exoc3|EXOC3]]|0.458|
|[[:human genes:d:ddx1|DDX1]]|0.458|
|[[:human genes:e:elp3|ELP3]]|0.456|
|[[:human genes:b:bptf|BPTF]]|0.454|
|[[:human genes:t:txnl4b|TXNL4B]]|0.452|
|[[:human genes:d:dhx29|DHX29]]|0.452|
|[[:human genes:c:cdipt|CDIPT]]|0.452|
|[[:human genes:l:lsm10|LSM10]]|0.451|
|[[:human genes:t:tprkb|TPRKB]]|0.45|
|[[:human genes:d:dnajc3|DNAJC3]]|0.45|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.448|
|[[:human genes:d:ddx20|DDX20]]|0.448|
|[[:human genes:e:eno1|ENO1]]|0.447|
|[[:human genes:s:srp68|SRP68]]|0.447|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.447|
|[[:human genes:z:zfx|ZFX]]|0.446|
|[[:human genes:p:papola|PAPOLA]]|0.446|
|[[:human genes:t:thoc3|THOC3]]|0.446|
|[[:human genes:g:gtf3a|GTF3A]]|0.446|
|[[:human genes:s:sec61g|SEC61G]]|0.445|
|[[:human genes:t:txnrd1|TXNRD1]]|0.445|
|[[:human genes:t:tsen2|TSEN2]]|0.445|
|[[:human genes:n:nupl2|NUPL2]]|0.445|
|[[:human genes:e:eef1e1|EEF1E1]]|0.445|
|[[:human genes:t:tbca|TBCA]]|0.444|
|[[:human genes:u:ube2j1|UBE2J1]]|0.444|
|[[:human genes:p:pax5|PAX5]]|0.444|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.444|
|[[:human genes:a:atf7ip|ATF7IP]]|0.443|
|[[:human genes:a:asxl2|ASXL2]]|0.443|
|[[:human genes:s:smarcd1|SMARCD1]]|0.442|
|[[:human genes:a:alg14|ALG14]]|0.441|
|[[:human genes:e:eif1ax|EIF1AX]]|0.441|
|[[:human genes:d:ddx39a|DDX39A]]|0.44|
|[[:human genes:u:ube2m|UBE2M]]|0.44|
|[[:human genes:z:znf259|ZNF259]]|0.439|
|[[:human genes:s:spcs2|SPCS2]]|0.439|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.438|
|[[:human genes:g:gemin8|GEMIN8]]|0.438|
|[[:human genes:e:eif4g1|EIF4G1]]|0.438|
|[[:human genes:w:wars|WARS]]|0.437|
|[[:human genes:d:ddx55|DDX55]]|0.437|
|[[:human genes:d:dhdds|DHDDS]]|0.437|
|[[:human genes:c:chchd4|CHCHD4]]|0.437|
|[[:human genes:c:cbx3|CBX3]]|0.437|
|[[:human genes:g:gemin6|GEMIN6]]|0.434|
|[[:human genes:p:pisd|PISD]]|0.434|
|[[:human genes:s:slc25a19|SLC25A19]]|0.434|
|[[:human genes:h:hhex|HHEX]]|0.434|
|[[:human genes:a:alg6|ALG6]]|0.433|
|[[:human genes:t:taf5l|TAF5L]]|0.433|
|[[:human genes:c:c21orf59|C21orf59]]|0.432|
|[[:human genes:h:hspa9|HSPA9]]|0.432|
|[[:human genes:s:stt3a|STT3A]]|0.431|
|[[:human genes:n:naf1|NAF1]]|0.431|
|[[:human genes:t:taf1a|TAF1A]]|0.431|
|[[:human genes:n:nxt1|NXT1]]|0.431|
|[[:human genes:u:usp22|USP22]]|0.43|
|[[:human genes:c:ctc1|CTC1]]|0.429|
|[[:human genes:p:pik3r4|PIK3R4]]|0.429|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.428|
|[[:human genes:p:phb|PHB]]|0.428|
|[[:human genes:z:zrsr2|ZRSR2]]|0.427|
|[[:human genes:b:brpf1|BRPF1]]|0.426|
|[[:human genes:m:max|MAX]]|0.425|
|[[:human genes:m:maml1|MAML1]]|0.425|
|[[:human genes:f:fh|FH]]|0.425|
|[[:human genes:v:vps41|VPS41]]|0.425|
|[[:human genes:w:wdr1|WDR1]]|0.425|
|[[:human genes:n:n6amt1|N6AMT1]]|0.424|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.424|
|[[:human genes:p:pdpk1|PDPK1]]|0.423|
|[[:human genes:a:atp2a2|ATP2A2]]|0.423|
|[[:human genes:r:rad1|RAD1]]|0.421|
|[[:human genes:r:runx1|RUNX1]]|0.421|
|[[:human genes:t:trim33|TRIM33]]|0.42|
|[[:human genes:c:cep57|CEP57]]|0.42|
|[[:human genes:s:suv420h1|SUV420H1]]|0.419|
|[[:human genes:c:cars|CARS]]|0.418|
|[[:human genes:a:atic|ATIC]]|0.418|
|[[:human genes:o:opa1|OPA1]]|0.417|
|[[:human genes:e:elac2|ELAC2]]|0.416|
|[[:human genes:w:wdr82|WDR82]]|0.416|
|[[:human genes:r:rbmx2|RBMX2]]|0.416|
|[[:human genes:d:dicer1|DICER1]]|0.416|
|[[:human genes:g:gemin7|GEMIN7]]|0.415|
|[[:human genes:a:atp5h|ATP5H]]|0.415|
|[[:human genes:r:rft1|RFT1]]|0.415|
|[[:human genes:a:abcf1|ABCF1]]|0.415|
|[[:human genes:m:mfn1|MFN1]]|0.415|
|[[:human genes:a:atp5d|ATP5D]]|0.413|
|[[:human genes:t:tmem242|TMEM242]]|0.412|
|[[:human genes:g:gabpa|GABPA]]|0.412|
|[[:human genes:u:ubr5|UBR5]]|0.411|
|[[:human genes:s:sdha|SDHA]]|0.411|
|[[:human genes:a:atp5a1|ATP5A1]]|0.411|
|[[:human genes:d:derl2|DERL2]]|0.411|
|[[:human genes:b:brd9|BRD9]]|0.411|
|[[:human genes:c:chordc1|CHORDC1]]|0.411|
|[[:human genes:r:rpia|RPIA]]|0.411|
|[[:human genes:f:fnta|FNTA]]|0.411|
|[[:human genes:c:cops8|COPS8]]|0.41|
|[[:human genes:m:mocs3|MOCS3]]|0.409|
|[[:human genes:a:actc1|ACTC1]]|0.409|
|[[:human genes:f:flcn|FLCN]]|0.408|
|[[:human genes:c:cep350|CEP350]]|0.408|
|[[:human genes:s:spcs3|SPCS3]]|0.407|
|[[:human genes:s:sox7|SOX7]]|0.407|
|[[:human genes:t:trmt61a|TRMT61A]]|0.406|
|[[:human genes:f:fli1|FLI1]]|0.405|
|[[:human genes:n:ndufb1|NDUFB1]]|0.404|
|[[:human genes:x:xpo6|XPO6]]|0.404|
|[[:human genes:c:cul3|CUL3]]|0.404|
|[[:human genes:c:c15orf41|C15orf41]]|0.404|
|[[:human genes:t:tbcd|TBCD]]|0.404|
|[[:human genes:p:pdxk|PDXK]]|0.402|
|[[:human genes:p:pdcd5|PDCD5]]|0.401|
|[[:human genes:e:elf2|ELF2]]|0.4|
|[[:human genes:n:nsmce1|NSMCE1]]|0.4|
|[[:human genes:s:sec16a|SEC16A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 282/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|13/28|
|bone|9/26|
|breast|15/33|
|central nervous system|37/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|5/21|
|liver|8/20|
|lung|23/75|
|lymphocyte|8/16|
|ovary|11/26|
|pancreas|4/24|
|peripheral nervous system|5/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|5/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 241
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPTOR Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>