======= RPUSD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPUSD4
  * **<color #00a2e8>Official Name</color>**: RNA pseudouridine synthase D4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84881|84881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CM3|Q96CM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPUSD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPUSD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617488|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PseudoU synth 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudouridine synthase activity|
|positive regulation of mitochondrial translation|
|pseudouridine synthesis|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|positive regulation of translation|
|tRNA processing|
|positive regulation of cellular amide metabolic process|
|RNA modification|
|tRNA metabolic process|
|regulation of translation|
|mitochondrial matrix|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|RNA processing|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.76|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.71|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.76|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.88|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.91|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.95|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.01|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.06|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.09|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.17|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.17|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.19|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.2|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.26|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.3|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.34|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.38|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.43|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.738|
|[[:human genes:y:yars2|YARS2]]|0.73|
|[[:human genes:s:selrc1|SELRC1]]|0.729|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.701|
|[[:human genes:t:tars2|TARS2]]|0.697|
|[[:human genes:m:mrps6|MRPS6]]|0.69|
|[[:human genes:n:nars2|NARS2]]|0.689|
|[[:human genes:m:mrpl23|MRPL23]]|0.688|
|[[:human genes:m:mrps16|MRPS16]]|0.681|
|[[:human genes:m:mrps21|MRPS21]]|0.678|
|[[:human genes:v:vars2|VARS2]]|0.675|
|[[:human genes:d:dap3|DAP3]]|0.675|
|[[:human genes:m:mrps5|MRPS5]]|0.666|
|[[:human genes:g:gfm1|GFM1]]|0.663|
|[[:human genes:m:mrps34|MRPS34]]|0.661|
|[[:human genes:m:mrps14|MRPS14]]|0.661|
|[[:human genes:f:fastkd5|FASTKD5]]|0.654|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.652|
|[[:human genes:p:pars2|PARS2]]|0.649|
|[[:human genes:r:rbfa|RBFA]]|0.647|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.645|
|[[:human genes:s:sco2|SCO2]]|0.645|
|[[:human genes:q:qrsl1|QRSL1]]|0.643|
|[[:human genes:c:c12orf65|C12orf65]]|0.642|
|[[:human genes:c:cox16|COX16]]|0.642|
|[[:human genes:s:sars2|SARS2]]|0.64|
|[[:human genes:m:mrp63|MRP63]]|0.636|
|[[:human genes:m:mrps18a|MRPS18A]]|0.635|
|[[:human genes:g:gfm2|GFM2]]|0.635|
|[[:human genes:l:lars2|LARS2]]|0.633|
|[[:human genes:d:dars2|DARS2]]|0.633|
|[[:human genes:m:mrps26|MRPS26]]|0.63|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.622|
|[[:human genes:e:ears2|EARS2]]|0.622|
|[[:human genes:f:ftsj2|FTSJ2]]|0.621|
|[[:human genes:m:mtg2|MTG2]]|0.621|
|[[:human genes:b:bcs1l|BCS1L]]|0.619|
|[[:human genes:m:mrpl47|MRPL47]]|0.616|
|[[:human genes:m:mrpl53|MRPL53]]|0.614|
|[[:human genes:r:rars2|RARS2]]|0.614|
|[[:human genes:f:fars2|FARS2]]|0.612|
|[[:human genes:m:mars2|MARS2]]|0.606|
|[[:human genes:m:mtpap|MTPAP]]|0.603|
|[[:human genes:m:mrpl12|MRPL12]]|0.602|
|[[:human genes:g:gatc|GATC]]|0.599|
|[[:human genes:m:mrps24|MRPS24]]|0.599|
|[[:human genes:t:tefm|TEFM]]|0.598|
|[[:human genes:t:tufm|TUFM]]|0.597|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.596|
|[[:human genes:m:mrpl20|MRPL20]]|0.595|
|[[:human genes:c:coa3|COA3]]|0.594|
|[[:human genes:s:slc25a26|SLC25A26]]|0.592|
|[[:human genes:m:mrps2|MRPS2]]|0.585|
|[[:human genes:p:pdss1|PDSS1]]|0.582|
|[[:human genes:n:ndufa3|NDUFA3]]|0.581|
|[[:human genes:p:pet112|PET112]]|0.581|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.58|
|[[:human genes:m:mrps25|MRPS25]]|0.576|
|[[:human genes:n:ndufb11|NDUFB11]]|0.575|
|[[:human genes:m:mrpl55|MRPL55]]|0.573|
|[[:human genes:c:c17orf89|C17orf89]]|0.572|
|[[:human genes:c:c10orf2|C10orf2]]|0.571|
|[[:human genes:c:coa6|COA6]]|0.57|
|[[:human genes:c:coq2|COQ2]]|0.57|
|[[:human genes:m:mrps23|MRPS23]]|0.563|
|[[:human genes:p:pnpt1|PNPT1]]|0.562|
|[[:human genes:m:mrps11|MRPS11]]|0.561|
|[[:human genes:a:aars2|AARS2]]|0.559|
|[[:human genes:t:trub2|TRUB2]]|0.553|
|[[:human genes:p:polg2|POLG2]]|0.552|
|[[:human genes:m:mrpl15|MRPL15]]|0.551|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.55|
|[[:human genes:t:tomm20|TOMM20]]|0.548|
|[[:human genes:m:mrps12|MRPS12]]|0.547|
|[[:human genes:c:cox15|COX15]]|0.546|
|[[:human genes:c:cox7b|COX7B]]|0.544|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.543|
|[[:human genes:m:mterfd2|MTERFD2]]|0.542|
|[[:human genes:w:wbscr16|WBSCR16]]|0.541|
|[[:human genes:r:rpusd3|RPUSD3]]|0.541|
|[[:human genes:c:cox17|COX17]]|0.538|
|[[:human genes:m:mrps9|MRPS9]]|0.538|
|[[:human genes:m:mrps22|MRPS22]]|0.537|
|[[:human genes:m:mrpl3|MRPL3]]|0.536|
|[[:human genes:c:cox6c|COX6C]]|0.535|
|[[:human genes:m:mrps10|MRPS10]]|0.534|
|[[:human genes:p:polg|POLG]]|0.528|
|[[:human genes:m:mrpl44|MRPL44]]|0.528|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.527|
|[[:human genes:t:tmem242|TMEM242]]|0.527|
|[[:human genes:c:chchd4|CHCHD4]]|0.527|
|[[:human genes:m:mrpl4|MRPL4]]|0.526|
|[[:human genes:m:mrps7|MRPS7]]|0.524|
|[[:human genes:m:mtg1|MTG1]]|0.524|
|[[:human genes:t:timm8b|TIMM8B]]|0.522|
|[[:human genes:m:mrpl45|MRPL45]]|0.517|
|[[:human genes:m:mrpl34|MRPL34]]|0.516|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.516|
|[[:human genes:c:cox11|COX11]]|0.516|
|[[:human genes:m:mrpl18|MRPL18]]|0.513|
|[[:human genes:h:hars2|HARS2]]|0.513|
|[[:human genes:a:atp5c1|ATP5C1]]|0.512|
|[[:human genes:p:pet117|PET117]]|0.511|
|[[:human genes:m:mettl17|METTL17]]|0.511|
|[[:human genes:n:ndufa2|NDUFA2]]|0.511|
|[[:human genes:c:cars2|CARS2]]|0.509|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.509|
|[[:human genes:m:mrps35|MRPS35]]|0.508|
|[[:human genes:n:ndufc2|NDUFC2]]|0.506|
|[[:human genes:m:mrps33|MRPS33]]|0.505|
|[[:human genes:r:rpia|RPIA]]|0.504|
|[[:human genes:p:pgm3|PGM3]]|0.503|
|[[:human genes:i:iba57|IBA57]]|0.502|
|[[:human genes:e:elac2|ELAC2]]|0.5|
|[[:human genes:t:tomm22|TOMM22]]|0.499|
|[[:human genes:m:mtif3|MTIF3]]|0.498|
|[[:human genes:h:hccs|HCCS]]|0.498|
|[[:human genes:a:atp5d|ATP5D]]|0.498|
|[[:human genes:d:dhrsx|DHRSX]]|0.497|
|[[:human genes:m:mipep|MIPEP]]|0.496|
|[[:human genes:u:uqcrq|UQCRQ]]|0.496|
|[[:human genes:m:mrpl39|MRPL39]]|0.494|
|[[:human genes:c:chchd1|CHCHD1]]|0.493|
|[[:human genes:m:mcat|MCAT]]|0.492|
|[[:human genes:l:lrpprc|LRPPRC]]|0.492|
|[[:human genes:n:ndufb5|NDUFB5]]|0.49|
|[[:human genes:m:mrpl11|MRPL11]]|0.489|
|[[:human genes:d:dhx30|DHX30]]|0.488|
|[[:human genes:n:ndufa1|NDUFA1]]|0.487|
|[[:human genes:e:ecsit|ECSIT]]|0.487|
|[[:human genes:m:mrpl41|MRPL41]]|0.486|
|[[:human genes:m:mrpl36|MRPL36]]|0.485|
|[[:human genes:t:triap1|TRIAP1]]|0.485|
|[[:human genes:d:dnlz|DNLZ]]|0.484|
|[[:human genes:w:wars2|WARS2]]|0.483|
|[[:human genes:c:coq6|COQ6]]|0.483|
|[[:human genes:m:mrpl43|MRPL43]]|0.482|
|[[:human genes:n:ndufs7|NDUFS7]]|0.481|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.481|
|[[:human genes:m:mrpl46|MRPL46]]|0.48|
|[[:human genes:n:ndufb3|NDUFB3]]|0.478|
|[[:human genes:u:uqcc2|UQCC2]]|0.478|
|[[:human genes:l:lsm10|LSM10]]|0.477|
|[[:human genes:m:malsu1|MALSU1]]|0.476|
|[[:human genes:t:tmem261|TMEM261]]|0.475|
|[[:human genes:n:ndufa11|NDUFA11]]|0.474|
|[[:human genes:c:coq4|COQ4]]|0.473|
|[[:human genes:m:mterfd1|MTERFD1]]|0.472|
|[[:human genes:o:opa1|OPA1]]|0.471|
|[[:human genes:m:mrpl1|MRPL1]]|0.471|
|[[:human genes:c:coa5|COA5]]|0.47|
|[[:human genes:m:mrpl33|MRPL33]]|0.47|
|[[:human genes:m:mrpl22|MRPL22]]|0.469|
|[[:human genes:c:coq3|COQ3]]|0.468|
|[[:human genes:t:tomm6|TOMM6]]|0.468|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.467|
|[[:human genes:a:atp5sl|ATP5SL]]|0.466|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.465|
|[[:human genes:m:mrpl2|MRPL2]]|0.464|
|[[:human genes:c:crls1|CRLS1]]|0.464|
|[[:human genes:a:atp5j|ATP5J]]|0.464|
|[[:human genes:p:polrmt|POLRMT]]|0.463|
|[[:human genes:u:uqcr10|UQCR10]]|0.46|
|[[:human genes:p:pmm2|PMM2]]|0.459|
|[[:human genes:a:atp5b|ATP5B]]|0.459|
|[[:human genes:n:ndufv1|NDUFV1]]|0.458|
|[[:human genes:s:ssbp1|SSBP1]]|0.457|
|[[:human genes:t:tpk1|TPK1]]|0.456|
|[[:human genes:a:aifm1|AIFM1]]|0.456|
|[[:human genes:t:tfb1m|TFB1M]]|0.455|
|[[:human genes:m:mrpl27|MRPL27]]|0.454|
|[[:human genes:m:mrpl13|MRPL13]]|0.453|
|[[:human genes:m:minos1|MINOS1]]|0.452|
|[[:human genes:c:coq7|COQ7]]|0.451|
|[[:human genes:t:tfam|TFAM]]|0.451|
|[[:human genes:p:ppcs|PPCS]]|0.449|
|[[:human genes:h:higd2a|HIGD2A]]|0.447|
|[[:human genes:c:cox5a|COX5A]]|0.447|
|[[:human genes:m:mrps27|MRPS27]]|0.446|
|[[:human genes:n:nfu1|NFU1]]|0.445|
|[[:human genes:r:romo1|ROMO1]]|0.445|
|[[:human genes:n:ndufs2|NDUFS2]]|0.442|
|[[:human genes:n:ndufb9|NDUFB9]]|0.441|
|[[:human genes:n:ndufb6|NDUFB6]]|0.441|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.439|
|[[:human genes:t:tamm41|TAMM41]]|0.438|
|[[:human genes:p:pet100|PET100]]|0.438|
|[[:human genes:f:fh|FH]]|0.438|
|[[:human genes:e:eral1|ERAL1]]|0.437|
|[[:human genes:t:timm17a|TIMM17A]]|0.435|
|[[:human genes:m:mrpl52|MRPL52]]|0.434|
|[[:human genes:t:tmem126b|TMEM126B]]|0.433|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.432|
|[[:human genes:p:ptcd1|PTCD1]]|0.431|
|[[:human genes:m:mrps17|MRPS17]]|0.429|
|[[:human genes:f:fastkd2|FASTKD2]]|0.429|
|[[:human genes:c:cycs|CYCS]]|0.428|
|[[:human genes:m:mrpl42|MRPL42]]|0.428|
|[[:human genes:a:atxn10|ATXN10]]|0.427|
|[[:human genes:m:mto1|MTO1]]|0.425|
|[[:human genes:t:tomm40|TOMM40]]|0.425|
|[[:human genes:m:mrpl35|MRPL35]]|0.425|
|[[:human genes:a:atp5e|ATP5E]]|0.423|
|[[:human genes:p:ptdss1|PTDSS1]]|0.422|
|[[:human genes:a:atp5a1|ATP5A1]]|0.421|
|[[:human genes:d:ddx28|DDX28]]|0.421|
|[[:human genes:g:glrx5|GLRX5]]|0.421|
|[[:human genes:m:mrpl49|MRPL49]]|0.42|
|[[:human genes:s:slc25a19|SLC25A19]]|0.42|
|[[:human genes:c:cox6b1|COX6B1]]|0.418|
|[[:human genes:p:prkrir|PRKRIR]]|0.418|
|[[:human genes:t:trmt10a|TRMT10A]]|0.418|
|[[:human genes:i:isca2|ISCA2]]|0.417|
|[[:human genes:s:srd5a3|SRD5A3]]|0.416|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.416|
|[[:human genes:m:mrpl17|MRPL17]]|0.415|
|[[:human genes:z:zrsr2|ZRSR2]]|0.412|
|[[:human genes:r:rpe|RPE]]|0.412|
|[[:human genes:m:mrps18b|MRPS18B]]|0.411|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.41|
|[[:human genes:t:tbrg4|TBRG4]]|0.409|
|[[:human genes:g:grsf1|GRSF1]]|0.409|
|[[:human genes:p:ppa2|PPA2]]|0.409|
|[[:human genes:d:dpagt1|DPAGT1]]|0.408|
|[[:human genes:v:vezt|VEZT]]|0.408|
|[[:human genes:a:atp5o|ATP5O]]|0.408|
|[[:human genes:m:mrpl51|MRPL51]]|0.407|
|[[:human genes:a:alas1|ALAS1]]|0.407|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.407|
|[[:human genes:t:taz|TAZ]]|0.405|
|[[:human genes:a:acad9|ACAD9]]|0.405|
|[[:human genes:a:alg8|ALG8]]|0.404|
|[[:human genes:n:ndufs5|NDUFS5]]|0.403|
|[[:human genes:t:trmt61a|TRMT61A]]|0.403|
|[[:human genes:t:thg1l|THG1L]]|0.403|
|[[:human genes:t:tomm7|TOMM7]]|0.402|
|[[:human genes:d:dohh|DOHH]]|0.402|
|[[:human genes:m:mrpl37|MRPL37]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPUSD4 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>