======= RRS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRS1
  * **<color #00a2e8>Official Name</color>**: ribosome biogenesis regulator 1 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23212|23212]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15050|Q15050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRS1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nucleolus|
|ribosomal large subunit export from nucleus|
|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|5S rRNA binding|
|endonucleolytic cleavage involved in rRNA processing|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|ribosome localization|
|ribosomal subunit export from nucleus|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, large subunit precursor|
|maturation of 5.8S rRNA|
|condensed nuclear chromosome|
|ribosomal large subunit assembly|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of SSU-rRNA|
|mitotic metaphase plate congression|
|metaphase plate congression|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|ribosomal large subunit biogenesis|
|establishment of chromosome localization|
|chromosome localization|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|hematopoietic progenitor cell differentiation|
|mitotic sister chromatid segregation|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|fibrillar center|
|sister chromatid segregation|
|mitotic nuclear division|
|protein export from nucleus|
|nuclear export|
|RNA phosphodiester bond hydrolysis|
|protein localization to nucleus|
|regulation of signal transduction by p53 class mediator|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|rRNA processing|
|RNA localization|
|nuclear chromosome segregation|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|organelle fission|
|establishment of organelle localization|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|hemopoiesis|
|organelle localization|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|immune system development|
|mitotic cell cycle|
|protein localization to organelle|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|intracellular protein transport|
|cell cycle process|
|endoplasmic reticulum|
|chromosome organization|
|cell cycle|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.7|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.82|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aamp|AAMP]]|0.448|
|[[:human genes:e:exosc1|EXOSC1]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.415|
|[[:human genes:i:ik|IK]]|0.409|
|[[:human genes:r:rrp15|RRP15]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 625/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|20/28|
|bone|21/26|
|breast|24/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|18/21|
|liver|16/20|
|lung|62/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|26/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 695
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRS1 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>