======= RS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RS1
  * **<color #00a2e8>Official Name</color>**: retinoschisin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6247|6247]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15537|O15537]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300839|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). {ECO:0000250|UniProtKB:Q9Z1L4, ECO:0000269|PubMed:19093009, ECO:0000305|PubMed:27114531}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adaptation of rhodopsin mediated signaling|
|light adaption|
|rhodopsin mediated signaling pathway|
|response to light intensity|
|phosphatidylinositol-5-phosphate binding|
|phototransduction, visible light|
|adaptation of signaling pathway|
|retina layer formation|
|phosphatidylinositol-3,5-bisphosphate binding|
|extrinsic component of plasma membrane|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|phototransduction|
|detection of visible light|
|retina morphogenesis in camera-type eye|
|neural retina development|
|phosphatidylserine binding|
|detection of light stimulus|
|phosphatidylinositol-4,5-bisphosphate binding|
|camera-type eye morphogenesis|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|retina development in camera-type eye|
|eye morphogenesis|
|cellular response to radiation|
|visual perception|
|sensory perception of light stimulus|
|sensory organ morphogenesis|
|response to light stimulus|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|protein homooligomerization|
|eye development|
|visual system development|
|sensory system development|
|response to radiation|
|protein complex oligomerization|
|sensory organ development|
|detection of stimulus|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|sensory perception|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.521|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18689
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RS1 Expression in NALM6 Cells: -1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>