======= RTTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTTN
  * **<color #00a2e8>Official Name</color>**: rotatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25914|25914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VV8|Q86VV8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RTTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RTTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610436|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary basal body organization|
|centriole-centriole cohesion|
|centriole replication|
|centriole assembly|
|centrosome duplication|
|centrosome cycle|
|microtubule organizing center organization|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|ciliary basal body|
|centriole|
|cilium organization|
|pattern specification process|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|organelle assembly|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.95|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.91|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.87|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.75|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.75|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.79|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.9|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.21|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|5.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf80|C14orf80]]|0.559|
|[[:human genes:p:pidd|PIDD]]|0.554|
|[[:human genes:c:c16orf59|C16orf59]]|0.537|
|[[:human genes:c:c2cd3|C2CD3]]|0.512|
|[[:human genes:c:cep120|CEP120]]|0.496|
|[[:human genes:c:cradd|CRADD]]|0.479|
|[[:human genes:o:odf2|ODF2]]|0.474|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.464|
|[[:human genes:o:ofd1|OFD1]]|0.449|
|[[:human genes:s:sclt1|SCLT1]]|0.445|
|[[:human genes:p:pibf1|PIBF1]]|0.434|
|[[:human genes:a:ankrd26|ANKRD26]]|0.429|
|[[:human genes:f:fopnl|FOPNL]]|0.429|
|[[:human genes:b:bub3|BUB3]]|0.418|
|[[:human genes:c:casp2|CASP2]]|0.411|
|[[:human genes:m:mad2l1|MAD2L1]]|0.402|
|[[:human genes:t:tube1|TUBE1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 146/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|3/28|
|bone|4/26|
|breast|6/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|5/21|
|liver|5/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|8/26|
|pancreas|2/24|
|peripheral nervous system|10/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RTTN Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>